Renaud Lesourne

Toulouse, 31024, France

Last Updated: 09/26/2026

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Found 21 publications

THEMIS: new insights into its evolution, structure, and function.

THEMIS: new insights into its evolution, structure, and function.

Journal: Trends in immunology
Published: November 10, 2025

THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA.

THEMIS promotes T cell development and maintenance by rising the signaling threshold of the inhibitory receptor BTLA.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: May 07, 2024

Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation.

Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation.

Journal: Nature immunology
Published: February 27, 2024

Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation.

Positive regulation of Vav1 by Themis controls CD4 T cell pathogenicity in a mouse model of central nervous system inflammation.

Journal: Cellular and molecular life sciences : CMLS
Published: October 13, 2023

THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals.

THEMIS enhances the magnitude of normal and neuroinflammatory type 1 immune responses by promoting TCR-independent signals.

Journal: Science signaling
Published: July 20, 2022

A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage.

A selective LIS1 requirement for mitotic spindle assembly discriminates distinct T-cell division mechanisms within the T-cell lineage.

Journal: eLife
Published: May 13, 2022

Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses.

Negative times negative equals positive, THEMIS sets the rule on thymic selection and peripheral T cell responses.

Journal: Biomedical journal
Published: November 10, 2021

CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.

CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: May 22, 2020

Regulatory mechanisms in T cell receptor signalling.

Regulatory mechanisms in T cell receptor signalling.

Journal: Nature reviews. Immunology
Published: May 24, 2018

Erratum: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.

Erratum: THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.

Journal: Nature immunology
Published: May 19, 2017

Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.

Grb2-Mediated Recruitment of USP9X to LAT Enhances Themis Stability following Thymic Selection.

Journal: Journal of immunology (Baltimore, Md. : 1950)
Published: April 20, 2017

THEMIS: Two Models, Different Thresholds.

THEMIS: Two Models, Different Thresholds.

Journal: Trends in immunology
Published: March 10, 2017
Showing 1-12 of 21

Last Updated: 09/26/2026