Riccardo Ronzoni

London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 14 publications

BMN 349, a small molecule inhibitor of Z alpha-1 antitrypsin polymerization, increases secretion and reduces intrahepatic inclusions in a mouse model of disease.

BMN 349, a small molecule inhibitor of Z alpha-1 antitrypsin polymerization, increases secretion and reduces intrahepatic inclusions in a mouse model of disease.

Journal: Hepatology (Baltimore, Md.)

Published: November 14, 2025

Susceptibility of alpha-1 antitrypsin deficiency variants to polymer-blocking therapy.

Susceptibility of alpha-1 antitrypsin deficiency variants to polymer-blocking therapy.

Journal: JCI insight

Published: April 16, 2025

Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.

Identification of an exosite at the neutrophil elastase/alpha-1-antitrypsin interface.

Journal: The FEBS journal

Published: May 22, 2024

Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors.

Reduction of Z alpha-1 antitrypsin polymers in human iPSC-hepatocytes and mice by LRRK2 inhibitors.

Journal: Hepatology (Baltimore, Md.)

Published: February 07, 2024

A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate.

A novel pathological mutant reveals the role of torsional flexibility in the serpin breach in adoption of an aggregation-prone intermediate.

Journal: The FEBS journal

Published: November 24, 2023

The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant.

The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant.

Journal: International journal of molecular sciences

Published: April 12, 2021

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

Journal: Bioorganic & medicinal chemistry letters

Published: December 02, 2020

Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.

Development of a small molecule that corrects misfolding and increases secretion of Z α1 -antitrypsin.

Journal: EMBO molecular medicine

Published: July 23, 2020

The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone.

The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone.

Journal: The FEBS journal

Published: June 22, 2020

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.

Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin.

Journal: JCI insight

Published: December 04, 2019

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1-induced collagen biosynthesis.

Journal: Science signaling

Published: May 23, 2019

Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.

Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.

Journal: Human molecular genetics

Published: January 31, 2018

Showing 1-12 of 14

Last Updated: 09/26/2026