Richard A. Noble

Newcastle Upon Tyne, ENG NE17RU, United Kingdom

Last Updated: 09/26/2026

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Found 11 publications

Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies.

Covalent Alkynylpyridopyrimidinones Targeting Cysteine 775 of the Epidermal Growth Factor Receptor Overcome Resistance to Current Therapies.

Journal: Journal of medicinal chemistry

Published: December 23, 2025

Author Correction: Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding.

Author Correction: Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding.

Journal: Communications chemistry

Published: May 19, 2025

Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding.

Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding.

Journal: Communications chemistry

Published: July 09, 2024

Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release.

Targeting Cytotoxic Agents through EGFR-Mediated Covalent Binding and Release.

Journal: Journal of medicinal chemistry

Published: August 30, 2023

Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.

Modulation of ERK5 Activity as a Therapeutic Anti-Cancer Strategy.

Journal: Journal of medicinal chemistry

Published: April 01, 2023

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.

Journal: Journal of medicinal chemistry

Published: April 25, 2022

Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.

Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.

Journal: British journal of cancer

Published: May 29, 2021

Engagement in video and audio narratives: contrasting self-report and physiological measures.

Engagement in video and audio narratives: contrasting self-report and physiological measures.

Journal: Scientific reports

Published: November 22, 2019

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study.

Safety and efficacy of the maximum tolerated dose of givinostat in polycythemia vera: a two-part Phase Ib/II study.

Journal: Leukemia

Published: October 15, 2019

Highly Potent Clickable Probe for Cellular Imaging of MDM2 and Assessing Dynamic Responses to MDM2-p53 Inhibition.

Highly Potent Clickable Probe for Cellular Imaging of MDM2 and Assessing Dynamic Responses to MDM2-p53 Inhibition.

Journal: Bioconjugate chemistry

Published: June 01, 2018

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.

Journal: Haematologica

Published: December 22, 2016

Showing 1-11 of 11

Last Updated: 09/26/2026