Richard J. Spears

20 Gordon Street
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 22 publications

Lipopolysaccharide confinement in the bacterial outer membrane is governed by interactions within the conserved Lipid A anchor.

Lipopolysaccharide confinement in the bacterial outer membrane is governed by interactions within the conserved Lipid A anchor.

Journal: The EMBO journal

Published: June 06, 2025

Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents.

Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents.

Journal: Chemical science

Published: January 17, 2024

Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH.

Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH.

Journal: RSC advances

Published: December 22, 2023

Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones.

Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones.

Journal: Biomacromolecules

Published: October 04, 2023

Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels.

Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels.

Journal: Chemical science

Published: September 21, 2023

Recent advances in N- and C-terminus cysteine protein bioconjugation.

Recent advances in N- and C-terminus cysteine protein bioconjugation.

Journal: Current opinion in chemical biology

Published: December 01, 2022

Correction: Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation.

Correction: Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation.

Journal: Chemical communications (Cambridge, England)

Published: November 04, 2022

Correction: Tyrosine bioconjugation - an emergent alternative.

Correction: Tyrosine bioconjugation - an emergent alternative.

Journal: Organic & biomolecular chemistry

Published: October 31, 2022

Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins.

Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins.

Journal: Chemical communications (Cambridge, England)

Published: April 08, 2022

Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.

Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.

Journal: Chemical science

Published: March 21, 2022

A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations.

A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations.

Journal: ACS chemical biology

Published: November 09, 2021

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold.

A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold.

Journal: Chemical communications (Cambridge, England)

Published: November 08, 2021

Showing 1-12 of 22

Last Updated: 09/26/2026