Rob Leurs

Amsterdam, NH 1081HZ, Netherlands

Last Updated: 09/26/2026

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Found 158 publications

A Systematic Benchmark Study of Free Energy Methods for Quantifying Light-Responsive Binding Affinities of Photoswitchable Antagonists of Beta-Adrenergic Receptors.

A Systematic Benchmark Study of Free Energy Methods for Quantifying Light-Responsive Binding Affinities of Photoswitchable Antagonists of Beta-Adrenergic Receptors.

Journal: Journal of medicinal chemistry

Published: April 14, 2026

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.

Journal: British journal of pharmacology

Published: December 29, 2025

Leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands: application to the histamine H1 receptor.

Leveraging fragment-based drug discovery to advance 3D scaffolds into potent ligands: application to the histamine H1 receptor.

Journal: RSC medicinal chemistry

Published: December 02, 2025

Optical control of H1 receptor signaling with a BODIPY-photocaged antihistamine.

Optical control of H1 receptor signaling with a BODIPY-photocaged antihistamine.

Journal: Biochemical pharmacology

Published: November 25, 2025

Design and synthesis of photoswitchable desloratadine ligands for histamine H1 receptor photopharmacology.

Design and synthesis of photoswitchable desloratadine ligands for histamine H1 receptor photopharmacology.

Journal: RSC medicinal chemistry

Published: July 07, 2025

Photo-clenbuterol: Optical Control of β2-Adrenergic Receptor Signaling by Photoswitchable Ligand Efficacy.

Photo-clenbuterol: Optical Control of β2-Adrenergic Receptor Signaling by Photoswitchable Ligand Efficacy.

Journal: Journal of medicinal chemistry

Published: June 10, 2025

Inhibition of constitutive activity of the atypical chemokine receptor 3 by the small-molecule inverse agonist VUF16840.

Inhibition of constitutive activity of the atypical chemokine receptor 3 by the small-molecule inverse agonist VUF16840.

Journal: Molecular pharmacology

Published: March 25, 2025

Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.

Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.

Journal: Nature communications

Published: January 08, 2025

Recent Developments in the Optical Control of Adrenergic Signaling.

Recent Developments in the Optical Control of Adrenergic Signaling.

Journal: Medicinal research reviews

Published: December 31, 2024

Probing the Histamine H1 Receptor Binding Site to Explore Ligand Binding Kinetics.

Probing the Histamine H1 Receptor Binding Site to Explore Ligand Binding Kinetics.

Journal: Journal of medicinal chemistry

Published: December 26, 2024

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.

Journal: Science advances

Published: December 06, 2024

Characterization of [3H]AZ12464237 as a high affinity, non-nucleotide antagonist radioligand for the P2Y12 receptor.

Characterization of [3H]AZ12464237 as a high affinity, non-nucleotide antagonist radioligand for the P2Y12 receptor.

Journal: Biochemical pharmacology

Published: November 11, 2024

Showing 1-12 of 158

Last Updated: 09/26/2026