Robert G. Britton

Leicester, ENG LE19HN, United Kingdom

Last Updated: 09/26/2026

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Found 23 publications

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

More than an attachment module: covalent inhibitor warheads influence BTK dynamics and function.

Journal: bioRxiv : the preprint server for biology

Published: May 18, 2026

Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.

Computationally guided design of N4-(2-methyl-2H-indazol-6-yl)-N2-phenylpyrimidine-2,4-diamine inhibitors of EGFR kinase targeting Cys797.

Journal: Bioorganic & medicinal chemistry

Published: October 07, 2025

An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes.

An old spice with new tricks: Curcumin targets adenoma and colorectal cancer stem-like cells associated with poor survival outcomes.

Journal: Cancer letters

Published: March 28, 2025

Probing the Effect of Protein and Inhibitor Conformational Flexibility on the Reaction of Rocelitinib-Like Covalent Inhibitors of Epidermal Growth Factor Receptor. A Quantum Mechanics/Molecular Mechanics Study.

Probing the Effect of Protein and Inhibitor Conformational Flexibility on the Reaction of Rocelitinib-Like Covalent Inhibitors of Epidermal Growth Factor Receptor. A Quantum Mechanics/Molecular Mechanics Study.

Journal: Journal of chemical information and modeling

Published: March 18, 2025

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Journal: eLife

Published: December 27, 2024

Design, preparation and biological evaluation of new Rociletinib-inspired analogs as irreversible EGFR inhibitors to treat non-small-cell-lung cancer.

Design, preparation and biological evaluation of new Rociletinib-inspired analogs as irreversible EGFR inhibitors to treat non-small-cell-lung cancer.

Journal: Bioorganic & medicinal chemistry

Published: July 26, 2024

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia.

Journal: bioRxiv : the preprint server for biology

Published: January 08, 2024

Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities.

Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities.

Journal: International journal of molecular sciences

Published: December 03, 2023

BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib.

BTK mutations in patients with chronic lymphocytic leukemia receiving tirabrutinib.

Journal: Blood advances

Published: November 21, 2022

Determination of N7-glycidamide guanine adducts in human blood DNA following exposure to dietary acrylamide using liquid chromatography/tandem mass spectrometry.

Determination of N7-glycidamide guanine adducts in human blood DNA following exposure to dietary acrylamide using liquid chromatography/tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM

Published: November 03, 2021

Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells.

Increased mitochondrial proline metabolism sustains proliferation and survival of colorectal cancer cells.

Journal: PloS one

Published: August 10, 2021

Distribution and metabolism of [14C]-resveratrol in human prostate tissue after oral administration of a "dietary-achievable" or "pharmacological" dose: what are the implications for anticancer activity?

Distribution and metabolism of [14C]-resveratrol in human prostate tissue after oral administration of a "dietary-achievable" or "pharmacological" dose: what are the implications for anticancer activity?

Journal: The American journal of clinical nutrition

Published: August 08, 2020

Showing 1-12 of 23

Last Updated: 09/26/2026