Roberta Filograna

Stockholm, AB, Sweden

Last Updated: 09/26/2026

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Found 30 publications

Cardiomyocyte-intrinsic somatic mtDNA mutations induce an OXPHOS-dependent immune response and promote progressive heart failure.

Cardiomyocyte-intrinsic somatic mtDNA mutations induce an OXPHOS-dependent immune response and promote progressive heart failure.

Journal: Science advances
Published: September 04, 2026

Pathogenic POLRMT variants in mice impair mtDNA transcription and affect perinatal survival.

Pathogenic POLRMT variants in mice impair mtDNA transcription and affect perinatal survival.

Journal: JCI insight
Published: August 14, 2025

The mitochondrial protein TMEM177 fine-tunes mammalian cytochrome c oxidase assembly.

The mitochondrial protein TMEM177 fine-tunes mammalian cytochrome c oxidase assembly.

Journal: Mitochondrion
Published: August 11, 2025

Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice.

Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice.

Journal: eLife
Published: June 30, 2025

Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation.

Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation.

Journal: Cells
Published: May 15, 2025

The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain.

The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid homeostasis in the mouse brain.

Journal: Cell death & disease
Published: January 10, 2025

High mitochondrial DNA levels accelerate lung adenocarcinoma progression.

High mitochondrial DNA levels accelerate lung adenocarcinoma progression.

Journal: Science advances
Published: November 01, 2024

PARKIN is not required to sustain OXPHOS function in adult mammalian tissues.

PARKIN is not required to sustain OXPHOS function in adult mammalian tissues.

Journal: NPJ Parkinson's disease
Published: September 12, 2023

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations.

Journal: JCI insight
Published: December 06, 2022

Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.

Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity.

Journal: Nature metabolism
Published: November 03, 2022

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes.

Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes.

Journal: Cell metabolism
Published: October 03, 2022

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

A role for BCL2L13 and autophagy in germline purifying selection of mtDNA.

Journal: PLoS genetics
Published: September 16, 2022
Showing 1-12 of 30

Last Updated: 09/26/2026