Roberto Iacone

Allschwil, BL 4123, Switzerland

Last Updated: 09/26/2026

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Found 15 publications

Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models.

Claudin-1 targeting suppresses tumor growth, invasion, and metastasis in patient-derived cholangiocarcinoma models.

Journal: Science translational medicine

Published: June 03, 2026

Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis.

Claudin-1 is a mediator and therapeutic target in primary sclerosing cholangitis.

Journal: Journal of hepatology

Published: September 13, 2024

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity.

A monoclonal antibody targeting nonjunctional claudin-1 inhibits fibrosis in patient-derived models by modulating cell plasticity.

Journal: Science translational medicine

Published: December 21, 2022

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment.

Treatment of HCC with claudin-1-specific antibodies suppresses carcinogenic signaling and reprograms the tumor microenvironment.

Journal: Journal of hepatology

Published: February 21, 2022

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.

N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration.

Journal: Matrix biology : journal of the International Society for Matrix Biology

Published: December 23, 2017

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.

HtrA1 activation is driven by an allosteric mechanism of inter-monomer communication.

Journal: Scientific reports

Published: June 26, 2017

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.

Journal: EBioMedicine

Published: March 15, 2017

Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.

Molecular Phenotyping Combines Molecular Information, Biological Relevance, and Patient Data to Improve Productivity of Early Drug Discovery.

Journal: Cell chemical biology

Published: January 09, 2017

Generation of functional podocytes from human induced pluripotent stem cells.

Generation of functional podocytes from human induced pluripotent stem cells.

Journal: Stem cell research

Published: October 27, 2015

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.

Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells.

Journal: Nature cell biology

Published: September 16, 2014

Nanog induces hyperplasia without initiating tumors.

Nanog induces hyperplasia without initiating tumors.

Journal: Stem cell research

Published: July 25, 2014

Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells.

Journal: Cell reports

Published: May 14, 2014

Showing 1-12 of 15

Last Updated: 09/26/2026