Rolf W. Hartmann
Saarbruecken, SL 66123, Germany
Last Updated: 09/26/2026
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Found 159 publications
Discovery and optimization of thiazole-based quorum sensing inhibitors as potent blockers of Pseudomonas aeruginosa pathogenicity.
Journal: European journal of medicinal chemistry
Published: April 07, 2024
Inhibitors of the Elastase LasB for the Treatment of Pseudomonas aeruginosa Lung Infections.
Journal: ACS central science
Published: August 31, 2023
Modeling the Effect of Hydrophobicity on the Passive Permeation of Solutes across a Bacterial Model Membrane.
Journal: Journal of chemical information and modeling
Published: October 10, 2022
Towards Translation of PqsR Inverse Agonists: From In Vitro Efficacy Optimization to In Vivo Proof-of-Principle.
Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: August 03, 2022
Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa.
Journal: ACS infectious diseases
Published: April 22, 2022
N-Aryl Mercaptopropionamides as Broad-Spectrum Inhibitors of Metallo-β-Lactamases.
Journal: Journal of medicinal chemistry
Published: February 21, 2022
Substrate-Inspired Fragment Merging and Growing Affords Efficacious LasB Inhibitors.
Journal: Angewandte Chemie (International ed. in English)
Published: September 09, 2021
Metabolic Profiling of S-praziquantel: Structure Elucidation Using the Crystalline Sponge Method in Combination with Mass Spectrometry and Nuclear Magnetic Resonance.
Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: September 02, 2021
17β-Hydroxysteroid Dehydrogenase Type 1 Inhibition: A Potential Treatment Option for Non-Small Cell Lung Cancer.
Journal: ACS medicinal chemistry letters
Published: August 27, 2021
Structure-Activity Relationship and Mode-Of-Action Studies Highlight 1-(4-Biphenylylmethyl)-1H-imidazole-Derived Small Molecules as Potent CYP121 Inhibitors.
Journal: ChemMedChem
Published: April 27, 2021
From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity.
Journal: Journal of medicinal chemistry
Published: April 01, 2021
Crystalline sponge affinity screening: A fast tool for soaking condition optimization without the need of X-ray diffraction analysis.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Published: February 23, 2021
Last Updated: 09/26/2026