Romain Sigaud
Jena, TH 07743, Germany
Last Updated: 09/26/2026
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Found 17 publications
Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma.
Journal: iScience
Published: May 07, 2025
Association of phosphorylation status of ERK and genetic MAPK alterations in pediatric tumors.
Journal: Scientific reports
Published: January 08, 2025
Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models.
Journal: Signal transduction and targeted therapy
Published: November 06, 2024
A spatial map of MAPK-activated immunosuppressive myeloid populations in pediatric low-grade glioma.
A spatial map of MAPK-activated immunosuppressive myeloid populations in pediatric low-grade glioma.
Journal: Nature immunology
Published: October 17, 2024
MOST wanted: navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models.
Journal: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
Published: March 28, 2024
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
Journal: Journal of neuro-oncology
Published: February 27, 2024
Combination drug screen identifies synergistic drug interaction of BCL-XL and class I histone deacetylase inhibitors in MYC-amplified medulloblastoma cells.
Journal: Journal of neuro-oncology
Published: November 01, 2023
Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.
Journal: Journal of neuro-oncology
Published: September 27, 2023
Integrative multi-omics reveals two biologically distinct groups of pilocytic astrocytoma.
Journal: Acta neuropathologica
Published: May 11, 2023
Corrigendum to 'Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry' [Eur J Cancer 180 (2023) 71-84].
Journal: European journal of cancer (Oxford, England : 1990)
Published: March 23, 2023
Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.
Journal: Journal of neuro-oncology
Published: March 21, 2023
Key Pharmacokinetic Parameters of 74 Pediatric Anticancer Drugs Providing Assistance in Preclinical Studies.
Journal: Clinical pharmacology and therapeutics
Published: March 03, 2023
Last Updated: 09/26/2026