Ronald Melki

Fontenay-sous-bois, France

Last Updated: 09/26/2026

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Found 166 publications

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture.

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture.

Journal: eLife

Published: August 27, 2026

Preformed Fibril Seeding Reshapes the Phosphorylated α-Synuclein Proximal Proteome in the Olfactory Bulb.

Preformed Fibril Seeding Reshapes the Phosphorylated α-Synuclein Proximal Proteome in the Olfactory Bulb.

Journal: bioRxiv : the preprint server for biology

Published: August 20, 2026

Multiple system atrophy-derived α-synuclein fibrils are more potent and display oligodendrocyte cell tropism compared to Parkinson's disease-derived fibrils.

Multiple system atrophy-derived α-synuclein fibrils are more potent and display oligodendrocyte cell tropism compared to Parkinson's disease-derived fibrils.

Journal: Neurobiology of disease

Published: May 10, 2026

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation.

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation.

Journal: FEBS open bio

Published: February 19, 2026

Design, Synthesis and Evaluation of the First 2-Alkynyl(aza)indole 18F Probe Targeting α-Synuclein Aggregates.

Design, Synthesis and Evaluation of the First 2-Alkynyl(aza)indole 18F Probe Targeting α-Synuclein Aggregates.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: September 04, 2025

α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons.

α-synuclein fibrils per se but not α-synuclein seeded aggregation causes mitochondrial dysfunction and cell death in human neurons.

Journal: Redox biology

Published: July 14, 2025

Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts.

Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts.

Journal: Frontiers in immunology

Published: June 05, 2025

In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-synucleinopathies.

In vivo validation of novel non-invasive PHP.eB AAVs as a potential therapeutic approach for alpha-synucleinopathies.

Journal: Acta neuropathologica communications

Published: May 27, 2025

Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies.

Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies.

Journal: Molecular systems biology

Published: May 19, 2025

Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use.

Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use.

Journal: Science advances

Published: April 02, 2025

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation.

Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation.

Journal: The EMBO journal

Published: December 01, 2024

Treatment with Tau fibrils impact Huntington's disease-related phenotypes in cell and mouse models.

Treatment with Tau fibrils impact Huntington's disease-related phenotypes in cell and mouse models.

Journal: Neurobiology of disease

Published: June 19, 2024

Showing 1-12 of 166

Last Updated: 09/26/2026