Roque Spinelli

Santa Fe De La Vera Cruz, S, Argentina

Last Updated: 09/26/2026

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Found 17 publications

A nature-inspired peptide from the Boana cordobae frog as a potent and reversible AChE inhibitor with anti-amyloid and neuroprotective activities.

A nature-inspired peptide from the Boana cordobae frog as a potent and reversible AChE inhibitor with anti-amyloid and neuroprotective activities.

Journal: Bioorganic chemistry

Published: November 26, 2025

N-methylation of bioactive peptides as a conformational constraint tool to improve enzymatic stability.

N-methylation of bioactive peptides as a conformational constraint tool to improve enzymatic stability.

Journal: Methods in enzymology

Published: November 20, 2025

Cost-effective synthesis of a chromogenic substrate for SARS-CoV-2 Mpro and development of a miniaturized high-throughput inhibition assay.

Cost-effective synthesis of a chromogenic substrate for SARS-CoV-2 Mpro and development of a miniaturized high-throughput inhibition assay.

Journal: Methods in enzymology

Published: November 20, 2025

Fighting Alzheimer's naturally: Peptides as multitarget drug leads.

Fighting Alzheimer's naturally: Peptides as multitarget drug leads.

Journal: Bioorganic & medicinal chemistry letters

Published: April 21, 2025

Amphibian-Derived Peptides as Natural Inhibitors of SARS-CoV-2 Main Protease (Mpro): A Combined In Vitro and In Silico Approach.

Amphibian-Derived Peptides as Natural Inhibitors of SARS-CoV-2 Main Protease (Mpro): A Combined In Vitro and In Silico Approach.

Journal: Chemistry & biodiversity

Published: December 03, 2024

Specific Rosetta-based protein-peptide prediction protocol allows the design of novel cholinesterase inhibitor peptides.

Specific Rosetta-based protein-peptide prediction protocol allows the design of novel cholinesterase inhibitor peptides.

Journal: Bioorganic chemistry

Published: November 12, 2024

Toxicity Evaluation of Anti-cholinesterasic Amphibian Extracts by MTT and an Optimized Artemia salina Test.

Toxicity Evaluation of Anti-cholinesterasic Amphibian Extracts by MTT and an Optimized Artemia salina Test.

Journal: Chemistry & biodiversity

Published: September 06, 2023

Acetylcholine hydrolytic activity of fibrillated β-amyloid (1-40) peptide.

Acetylcholine hydrolytic activity of fibrillated β-amyloid (1-40) peptide.

Journal: Amino acids

Published: June 27, 2023

D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides.

D- and N-Methyl Amino Acids for Modulating the Therapeutic Properties of Antimicrobial Peptides and Lipopeptides.

Journal: Antibiotics (Basel, Switzerland)

Published: April 06, 2023

Inhibition of Human Cholinesterases and in vitro β-Amyloid Aggregation by Rationally Designed Peptides.

Inhibition of Human Cholinesterases and in vitro β-Amyloid Aggregation by Rationally Designed Peptides.

Journal: ChemMedChem

Published: December 19, 2022

Development of low-cost cage-like particles to formulate veterinary vaccines.

Development of low-cost cage-like particles to formulate veterinary vaccines.

Journal: Veterinary immunology and immunopathology

Published: February 03, 2022

Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants.

Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants.

Journal: Amino acids

Published: August 02, 2021

Showing 1-12 of 17

Last Updated: 09/26/2026