Rosemary M. Burke

University College London Hospitals FT
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 50 publications

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Fragment-Based Discovery of Potent RNA-Competitive Inhibitors of the DEAH-Box RNA Helicase DHX8.

Journal: Journal of medicinal chemistry
Published: March 06, 2026

Erratum: iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.

Erratum: iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.

Journal: iScience
Published: April 22, 2024

Community-level variation in TB testing history in Blantyre, Malawi.

Community-level variation in TB testing history in Blantyre, Malawi.

Journal: The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Published: February 02, 2024

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

Design, Synthesis, and Evaluation of Inhibitors of Hedgehog Acyltransferase.

Journal: Journal of medicinal chemistry
Published: January 10, 2024

Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.

Determination of Ligand-Binding Affinity (Kd) Using Transverse Relaxation Rate (R2) in the Ligand-Observed 1H NMR Experiment and Applications to Fragment-Based Drug Discovery.

Journal: Journal of medicinal chemistry
Published: July 19, 2023

A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity.

A Degron Blocking Strategy Towards Improved CRL4CRBN Recruiting PROTAC Selectivity.

Journal: Chembiochem : a European journal of chemical biology
Published: May 10, 2023

iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.

iTAG an optimized IMiD-induced degron for targeted protein degradation in human and murine cells.

Journal: iScience
Published: April 12, 2023

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal: Journal of medicinal chemistry
Published: April 07, 2023

Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.

Discovery of 2-(3-Benzamidopropanamido)thiazole-5-carboxylate Inhibitors of the Kinesin HSET (KIFC1) and the Development of Cellular Target Engagement Probes.

Journal: Journal of medicinal chemistry
Published: February 07, 2023

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays.

Journal: Scientific reports
Published: July 04, 2022

Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.

Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors.

Journal: Journal of medicinal chemistry
Published: June 03, 2022

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Journal: Journal of medicinal chemistry
Published: June 02, 2022
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Last Updated: 09/26/2026