Ryan A. Lafferty

Coleraine, NIR BT521SA, United Kingdom

Last Updated: 09/26/2026

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Found 25 publications

NPYR modulation: Potential for the next major advance in obesity and type 2 diabetes management?

NPYR modulation: Potential for the next major advance in obesity and type 2 diabetes management?

Journal: Peptides

Published: March 15, 2024

Novel enzyme-resistant pancreatic polypeptide analogs evoke pancreatic beta-cell rest, enhance islet cell turnover, and inhibit food intake in mice.

Novel enzyme-resistant pancreatic polypeptide analogs evoke pancreatic beta-cell rest, enhance islet cell turnover, and inhibit food intake in mice.

Journal: BioFactors (Oxford, England)

Published: December 14, 2023

Does glucose-dependent insulinotropic polypeptide receptor blockade as well as agonism have a role to play in management of obesity and diabetes?

Does glucose-dependent insulinotropic polypeptide receptor blockade as well as agonism have a role to play in management of obesity and diabetes?

Journal: The Journal of endocrinology

Published: October 26, 2023

GLP-1/GIP analogs: potential impact in the landscape of obesity pharmacotherapy.

GLP-1/GIP analogs: potential impact in the landscape of obesity pharmacotherapy.

Journal: Expert opinion on pharmacotherapy

Published: March 17, 2023

The glucagon receptor antagonist desHis1Pro4Glu9-glucagon(Lys12PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia.

The glucagon receptor antagonist desHis1Pro4Glu9-glucagon(Lys12PAL) alters alpha-cell turnover and lineage in mice, but does not cause alpha-cell hyperplasia.

Journal: Molecular and cellular endocrinology

Published: February 02, 2023

Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice.

Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice.

Journal: Biochemical pharmacology

Published: November 09, 2022

Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice.

Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice.

Journal: The Journal of endocrinology

Published: August 19, 2022

Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient GluCreERT2;ROSA26-eYFP diabetic mice.

Effects of artemether on pancreatic islet morphology, islet cell turnover and α-cell transdifferentiation in insulin-deficient GluCreERT2;ROSA26-eYFP diabetic mice.

Journal: The Journal of pharmacy and pharmacology

Published: May 24, 2022

Beneficial metabolic effects of recurrent periods of beta-cell rest and stimulation using stable neuropeptide Y1 and glucagon-like peptide-1 receptor agonists.

Beneficial metabolic effects of recurrent periods of beta-cell rest and stimulation using stable neuropeptide Y1 and glucagon-like peptide-1 receptor agonists.

Journal: Diabetes, obesity & metabolism

Published: April 27, 2022

Metabolic effects of combined glucagon receptor antagonism and glucagon-like peptide-1 receptor agonism in high fat fed mice.

Metabolic effects of combined glucagon receptor antagonism and glucagon-like peptide-1 receptor agonism in high fat fed mice.

Journal: Biochimie

Published: January 27, 2022

Ac3IV, a V1a and V1b receptor selective vasopressin analogue, protects against hydrocortisone-induced changes in pancreatic islet cell lineage.

Ac3IV, a V1a and V1b receptor selective vasopressin analogue, protects against hydrocortisone-induced changes in pancreatic islet cell lineage.

Journal: Peptides

Published: December 07, 2021

Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells.

Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells.

Journal: PloS one

Published: June 25, 2021

Showing 1-12 of 25

Last Updated: 09/26/2026