Ryan J. Asby

Cambridge, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 12 publications

A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK-RAS mutations.

A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK-RAS mutations.

Journal: Oncogene
Published: October 20, 2025

The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation.

The RNA helicase domain of NAT10 promotes the biogenesis of hypomodified ribosomes to enhance cancer cell proliferation.

Journal: Nature communications
Published: September 15, 2025

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition.

CREBBP inactivation sensitizes B cell acute lymphoblastic leukemia to ferroptotic cell death upon BCL2 inhibition.

Journal: Nature communications
Published: February 03, 2025

Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML.

Posttranscriptional depletion of ribosome biogenesis factors engenders therapeutic vulnerabilities in NPM1-mutant AML.

Journal: Blood
Published: July 12, 2024

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition.

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition.

Journal: Blood advances
Published: June 20, 2024

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.

Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis.

Journal: Nature
Published: March 19, 2024

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis.

Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis.

Journal: Science advances
Published: August 03, 2022

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell death.

Journal: Nature communications
Published: May 20, 2022

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma.

Unbiased cell surface proteomics identifies SEMA4A as an effective immunotherapy target for myeloma.

Journal: Blood
Published: December 14, 2021

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.

Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.

Journal: Molecular cell
Published: March 29, 2021

KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia.

KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia.

Journal: Blood advances
Published: July 02, 2020

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

Journal: The Journal of experimental medicine
Published: July 06, 2018
Showing 1-12 of 12

Last Updated: 09/26/2026