Ryotaro Saiki

Chuo, 2608675, Japan

Last Updated: 09/26/2026

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Found 19 publications

Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers.

Design, synthesis, and evaluation of polyamine-memantine hybrids as NMDA channel blockers.

Journal: Bioorganic & medicinal chemistry

Published: September 26, 2017

Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke.

Time dependent transition of the levels of protein-conjugated acrolein (PC-Acro), IL-6 and CRP in plasma during stroke.

Journal: eNeurologicalSci

Published: March 09, 2017

Activation of MMP-9 activity by acrolein in saliva from patients with primary Sjögren's syndrome and its mechanism.

Activation of MMP-9 activity by acrolein in saliva from patients with primary Sjögren's syndrome and its mechanism.

Journal: The international journal of biochemistry & cell biology

Published: December 17, 2016

Aggravation of brain infarction through an increase in acrolein production and a decrease in glutathione with aging.

Aggravation of brain infarction through an increase in acrolein production and a decrease in glutathione with aging.

Journal: Biochemical and biophysical research communications

Published: March 14, 2016

Toxic acrolein production due to Ca(2+) influx by the NMDA receptor during stroke.

Toxic acrolein production due to Ca(2+) influx by the NMDA receptor during stroke.

Journal: Atherosclerosis

Published: July 04, 2015

Spermidine and Ca(2+), but not Na(+), can permeate NMDA receptors consisting of GluN1 and GluN2A or GluN2B in the presence of Mg(2+).

Spermidine and Ca(2+), but not Na(+), can permeate NMDA receptors consisting of GluN1 and GluN2A or GluN2B in the presence of Mg(2+).

Journal: Biochemical and biophysical research communications

Published: June 09, 2015

Increase in acrolein-conjugated immunoglobulins in saliva from patients with primary Sjögren's syndrome.

Increase in acrolein-conjugated immunoglobulins in saliva from patients with primary Sjögren's syndrome.

Journal: Clinica chimica acta; international journal of clinical chemistry

Published: May 16, 2015

Polyphenol extract from Phellinus igniarius protects against acrolein toxicity in vitro and provides protection in a mouse stroke model.

Polyphenol extract from Phellinus igniarius protects against acrolein toxicity in vitro and provides protection in a mouse stroke model.

Journal: PloS one

Published: October 28, 2014

Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.

Distinguishing mild cognitive impairment from Alzheimer's disease with acrolein metabolites and creatinine in urine.

Journal: Clinica chimica acta; international journal of clinical chemistry

Published: October 26, 2014

Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2.

Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2.

Journal: PloS one

Published: February 10, 2014

Distinction between mild cognitive impairment and Alzheimer's disease by CSF amyloid β40 and β42, and protein-conjugated acrolein.

Distinction between mild cognitive impairment and Alzheimer's disease by CSF amyloid β40 and β42, and protein-conjugated acrolein.

Journal: Clinica chimica acta; international journal of clinical chemistry

Published: November 22, 2013

In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers.

In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers.

Journal: Bioorganic & medicinal chemistry letters

Published: March 16, 2013

Showing 1-12 of 19

Last Updated: 09/26/2026