Sarah K. Tschirner

Carl Neuberg Str. 1
Hannover, NI 30625, Germany

Last Updated: 09/26/2026

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Found 21 publications

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates.

Elenbecestat and Compound 89 Potently Inhibit BACE1 but Not BACE2 When Subchronically Dosed in Non-Human Primates.

Journal: Proteomics

Published: September 16, 2025

Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration.

Patient-Derived Neurons Exhibit α-Synuclein Pathology and Previously Unrecognized Major Histocompatibility Complex Class I Elevation in Mitochondrial Membrane Protein-Associated Neurodegeneration.

Journal: Movement disorders : official journal of the Movement Disorder Society

Published: July 17, 2025

Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin.

Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin.

Journal: Neuropathology and applied neurobiology

Published: June 12, 2025

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

BACE1 regulates sleep-wake cycle through both enzymatic and non-enzymatic actions.

Journal: EMBO reports

Published: April 25, 2025

Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.

Soluble VCAM-1 May Serve as a Pharmacodynamic CSF Marker to Monitor BACE2 Activity in Non-Human Primates.

Journal: Molecular & cellular proteomics : MCP

Published: September 26, 2024

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.

Cleavage site-directed antibodies reveal the prion protein in humans is shed by ADAM10 at Y226 and associates with misfolded protein deposits in neurodegenerative diseases.

Journal: Acta neuropathologica

Published: April 24, 2024

Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover.

Loss of CLN3 in microglia leads to impaired lipid metabolism and myelin turnover.

Journal: Communications biology

Published: March 13, 2024

Oxidized MIF is an Alzheimer's disease drug target relaying external risk factors to tau pathology.

Oxidized MIF is an Alzheimer's disease drug target relaying external risk factors to tau pathology.

Journal: Cell reports. Medicine

Published: March 20, 2023

The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.

The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling.

Journal: The Journal of clinical investigation

Published: March 17, 2023

ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.

ADAM10 and ADAM17 promote SARS-CoV-2 cell entry and spike protein-mediated lung cell fusion.

Journal: EMBO reports

Published: November 10, 2021

Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.

Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2.

Journal: Current opinion in neurobiology

Published: August 11, 2021

Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia.

Dysregulation of a specific immune-related network of genes biologically defines a subset of schizophrenia.

Journal: Translational psychiatry

Published: August 06, 2018

Showing 1-12 of 21

Last Updated: 09/26/2026