Seandean L. Harwood

Aarhus C, Denmark

Last Updated: 09/26/2026

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Found 31 publications

Antagonist nanobodies prevent protease inhibition by CD109.

Antagonist nanobodies prevent protease inhibition by CD109.

Journal: The Journal of biological chemistry

Published: December 08, 2025

Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition.

Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition.

Journal: Cell reports

Published: November 28, 2024

Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity.

Characterization of a Trispecific PD-L1 Blocking Antibody That Exhibits EGFR-Conditional 4-1BB Agonist Activity.

Journal: Antibodies (Basel, Switzerland)

Published: January 12, 2024

Engineering New Protease Inhibitors Using α2-Macroglobulin.

Engineering New Protease Inhibitors Using α2-Macroglobulin.

Journal: Methods in molecular biology (Clifton, N.J.)

Published: December 01, 2023

Proteolytic cleavage of the TGFβ co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane.

Proteolytic cleavage of the TGFβ co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane.

Journal: The FEBS journal

Published: November 16, 2023

Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.

Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Published: July 16, 2023

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring.

Cryo-EM analysis of complement C3 reveals a reversible major opening of the macroglobulin ring.

Journal: Nature structural & molecular biology

Published: June 16, 2023

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.

A PD-L1/EGFR bispecific antibody combines immune checkpoint blockade and direct anti-cancer action for an enhanced anti-tumor response.

Journal: Oncoimmunology

Published: April 28, 2023

Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1.

Characterization of a novel cold-adapted intracellular serine protease from the extremophile Planococcus halocryophilus Or1.

Journal: Frontiers in microbiology

Published: December 12, 2022

Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein.

Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: August 16, 2022

The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel.

The conformational change of the protease inhibitor α2-macroglobulin is triggered by the retraction of the cleaved bait region from a central channel.

Journal: The Journal of biological chemistry

Published: May 04, 2022

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer.

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer.

Journal: Oncoimmunology

Published: February 14, 2022

Showing 1-12 of 31

Last Updated: 09/26/2026