Sebastiaan C. Goulooze

Leiden, ZH, Netherlands

Last Updated: 09/26/2026

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Found 42 publications

Causal Directed Acyclic Graphs to Mitigate Confounding Bias in Exposure-Response Analyses.

Causal Directed Acyclic Graphs to Mitigate Confounding Bias in Exposure-Response Analyses.

Journal: CPT: pharmacometrics & systems pharmacology

Published: November 21, 2025

Tutorial on Causal Mediation Analysis for Pharmacometricians.

Tutorial on Causal Mediation Analysis for Pharmacometricians.

Journal: CPT: pharmacometrics & systems pharmacology

Published: October 02, 2025

Impact of Event-Related Treatment Modifications in Exposure-Response Analyses of Repeated Time-to-Event Data.

Impact of Event-Related Treatment Modifications in Exposure-Response Analyses of Repeated Time-to-Event Data.

Journal: CPT: pharmacometrics & systems pharmacology

Published: July 07, 2025

A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.

A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite.

Journal: Journal of clinical pharmacology

Published: February 23, 2025

The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship?

The Drug Titration Paradox in the Presence of Intra-Individual Variation: Can we Estimate the True Concentration-Effect Relationship?

Journal: The AAPS journal

Published: January 20, 2025

Development of a Joint Tumor Size-Overall Survival Modeling and Simulation Framework Supporting Oncology Development Decision-Making.

Development of a Joint Tumor Size-Overall Survival Modeling and Simulation Framework Supporting Oncology Development Decision-Making.

Journal: CPT: pharmacometrics & systems pharmacology

Published: September 18, 2024

Tutorial on Conditional Simulations With a Tumor Size-Overall Survival Model to Support Oncology Drug Development.

Tutorial on Conditional Simulations With a Tumor Size-Overall Survival Model to Support Oncology Drug Development.

Journal: CPT: pharmacometrics & systems pharmacology

Published: September 18, 2024

Integrated Population Pharmacokinetics of Daprodustat in Patients with Chronic Kidney Disease with Anemia.

Integrated Population Pharmacokinetics of Daprodustat in Patients with Chronic Kidney Disease with Anemia.

Journal: Clinical pharmacokinetics

Published: August 15, 2024

Time-varying covariates, overadjustment bias and mediation in pharmacokinetic/pharmacodynamic modeling.

Time-varying covariates, overadjustment bias and mediation in pharmacokinetic/pharmacodynamic modeling.

Journal: CPT: pharmacometrics & systems pharmacology

Published: April 14, 2024

Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development: extrapolations and exposure-response analyses.

Advances in pharmacokinetic-pharmacodynamic modelling for pediatric drug development: extrapolations and exposure-response analyses.

Journal: Expert review of clinical pharmacology

Published: December 09, 2023

Pharmacokinetics and pharmacodynamics of finerenone in patients with chronic kidney disease and type 2 diabetes: Insights based on FIGARO-DKD and FIDELIO-DKD.

Pharmacokinetics and pharmacodynamics of finerenone in patients with chronic kidney disease and type 2 diabetes: Insights based on FIGARO-DKD and FIDELIO-DKD.

Journal: Diabetes, obesity & metabolism

Published: September 06, 2023

Dose-Exposure-Response Analysis of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone on UACR and eGFR: An Analysis from FIDELIO-DKD.

Dose-Exposure-Response Analysis of the Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone on UACR and eGFR: An Analysis from FIDELIO-DKD.

Journal: Clinical pharmacokinetics

Published: March 24, 2022

Showing 1-12 of 42

Last Updated: 09/26/2026