Sebastian Hilscher

Halle, NI, Germany

Last Updated: 09/26/2026

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Found 14 publications

In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors.

In silico screening of a designed focused chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors.

Journal: Computers in biology and medicine

Published: March 13, 2025

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment.

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment.

Journal: Computers in biology and medicine

Published: January 29, 2025

Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer.

Development of potent and selective tetrahydro-β-carboline-based HDAC6 inhibitors with promising activity against triple-negative breast cancer.

Journal: RSC medicinal chemistry

Published: January 26, 2025

Unlocking the potential of novel tetrahydro-β-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation.

Unlocking the potential of novel tetrahydro-β-carboline-based HDAC6 inhibitors for colorectal cancer therapy: Design, synthesis and biological evaluation.

Journal: Bioorganic chemistry

Published: January 25, 2025

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment.

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment.

Journal: bioRxiv : the preprint server for biology

Published: December 16, 2024

The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells.

The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells.

Journal: Leukemia

Published: November 29, 2024

Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.

Utilization of an optimized AlphaFold protein model for structure-based design of a selective HDAC11 inhibitor with anti-neuroblastoma activity.

Journal: Archiv der Pharmazie

Published: June 14, 2024

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells.

Development of new pyrazoles as class I HDAC inhibitors: Synthesis, molecular modeling, and biological characterization in leukemia cells.

Journal: Archiv der Pharmazie

Published: May 31, 2024

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

Comparative Structure-Based Virtual Screening Utilizing Optimized AlphaFold Model Identifies Selective HDAC11 Inhibitor.

Journal: International journal of molecular sciences

Published: December 11, 2023

Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.

Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation.

Journal: Journal of medicinal chemistry

Published: October 30, 2023

Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells.

Design and synthesis of bioreductive prodrugs of class I histone deacetylase inhibitors and their biological evaluation in virally transfected acute myeloid leukemia cells.

Journal: Archiv der Pharmazie

Published: September 25, 2023

1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors.

1,3-Diphenylureido hydroxamate as a promising scaffold for generation of potent antimalarial histone deacetylase inhibitors.

Journal: Scientific reports

Published: August 17, 2023

Showing 1-12 of 14

Last Updated: 09/26/2026