Serena G. Giannelli

Milan, 20133, Italy

Last Updated: 09/26/2026

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Found 43 publications

MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes.

MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes.

Journal: Nature communications
Published: June 02, 2025

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment.

Elevated 24-hydroxycholesterol levels counteract okadaic acid-induced tau hyperphosphorylation and neuronal morphology impairment.

Journal: Neurobiology of disease
Published: February 27, 2025

The Emerging Role of PCSK9 in the Pathogenesis of Alzheimer's Disease: A Possible Target for the Disease Treatment.

The Emerging Role of PCSK9 in the Pathogenesis of Alzheimer's Disease: A Possible Target for the Disease Treatment.

Journal: International journal of molecular sciences
Published: November 25, 2024

Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.

Microglia-specific IL-10 gene delivery inhibits neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.

Journal: Science translational medicine
Published: August 21, 2024

Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer's Disease.

Altered Brain Cholesterol Machinery in a Down Syndrome Mouse Model: A Possible Common Feature with Alzheimer's Disease.

Journal: Antioxidants (Basel, Switzerland)
Published: March 06, 2024

New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets.

New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets.

Journal: iScience
Published: November 10, 2023

24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer's Disease.

24-Hydroxycholesterol Induces Tau Proteasome-Dependent Degradation via the SIRT1/PGC1α/Nrf2 Pathway: A Potential Mechanism to Counteract Alzheimer's Disease.

Journal: Antioxidants (Basel, Switzerland)
Published: February 03, 2023

Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells.

Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells.

Journal: Scientific reports
Published: November 09, 2022

ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis.

ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis.

Journal: Antioxidants (Basel, Switzerland)
Published: October 12, 2022

MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice.

MCT1-dependent energetic failure and neuroinflammation underlie optic nerve degeneration in Wolfram syndrome mice.

Journal: eLife
Published: July 11, 2022

Intrathymic AAV delivery results in therapeutic site-specific integration at TCR loci in mice.

Intrathymic AAV delivery results in therapeutic site-specific integration at TCR loci in mice.

Journal: Blood
Published: June 10, 2022

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.

Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications.

Journal: Cell death & disease
Published: January 11, 2022
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Last Updated: 09/26/2026