Seunghyun Ko
Vancouver, BC V5Z4H4, Canada
Last Updated: 09/26/2026
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Found 9 publications
Molecular and imaging biomarker responses to brain mutant HTT lowering in a mouse model of Huntington disease.
Journal: Molecular therapy. Nucleic acids
Published: May 06, 2025
Elevated plasma and CSF neurofilament light chain concentrations are stabilized in response to mutant huntingtin lowering in the brains of Huntington's disease mice.
Journal: Translational neurodegeneration
Published: May 06, 2024
Systemic delivery of mutant huntingtin lowering antisense oligonucleotides to the brain using apolipoprotein A-I nanodisks for Huntington disease.
Journal: Journal of controlled release : official journal of the Controlled Release Society
Published: August 13, 2023
Delivery of mutant huntingtin-lowering antisense oligonucleotides to the brain by intranasally administered apolipoprotein A-I nanodisks.
Journal: Journal of controlled release : official journal of the Controlled Release Society
Published: March 20, 2023
Cerebrospinal fluid mutant huntingtin is a biomarker for huntingtin lowering in the striatum of Huntington disease mice.
Journal: Neurobiology of disease
Published: September 16, 2021
Rescue of aberrant huntingtin palmitoylation ameliorates mutant huntingtin-induced toxicity.
Journal: Neurobiology of disease
Published: March 27, 2021
Mutant Huntingtin Is Cleared from the Brain via Active Mechanisms in Huntington Disease.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
Published: July 16, 2020
Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease.
Journal: Nucleic acids research
Published: June 06, 2019
An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes.
Journal: Human molecular genetics
Published: April 01, 2016
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Last Updated: 09/26/2026