Severine Begard

Lille, France

Last Updated: 09/26/2026

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Found 25 publications

Amplification of seeding-competent tau aggregates by PMCA in human and experimental tauopathies.

Amplification of seeding-competent tau aggregates by PMCA in human and experimental tauopathies.

Journal: Acta neuropathologica communications

Published: February 03, 2026

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease.

N-terminally acetylated Met11-Tau: a new pathological truncated Tau species with functional relevance in Alzheimer's disease.

Journal: Translational neurodegeneration

Published: October 21, 2025

Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology.

Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology.

Journal: Alzheimer's research & therapy

Published: May 15, 2025

Protein fingerprints of brain-derived extracellular vesicles predict types of tau pathology.

Protein fingerprints of brain-derived extracellular vesicles predict types of tau pathology.

Journal: Alzheimer's research & therapy

Published: February 28, 2025

Integration of Microfluidic Devices with Microelectrode Arrays to Functionally Assay Amyloid-β-Induced Synaptotoxicity.

Integration of Microfluidic Devices with Microelectrode Arrays to Functionally Assay Amyloid-β-Induced Synaptotoxicity.

Journal: ACS biomaterials science & engineering

Published: February 22, 2024

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice.

Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice.

Journal: Brain : a journal of neurology

Published: November 30, 2023

A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.

A selection and optimization strategy for single-domain antibodies targeting the PHF6 linear peptide within the tau intrinsically disordered protein.

Journal: The Journal of biological chemistry

Published: July 19, 2023

Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System.

Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System.

Journal: Cells

Published: February 15, 2023

Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease.

Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease.

Journal: Progress in neurobiology

Published: May 23, 2022

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: June 16, 2021

Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies.

Extracellular vesicles: Major actors of heterogeneity in tau spreading among human tauopathies.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: March 15, 2021

Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats.

Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats.

Journal: Nature biomedical engineering

Published: July 17, 2020

Showing 1-12 of 25

Last Updated: 09/26/2026