Severine Deforges

Bordeaux, France

Last Updated: 09/26/2026

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Found 11 publications

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Non-microglial downregulation of PLCG2 impairs synaptic function and elicits Alzheimer disease-related hallmarks.

Journal: bioRxiv : the preprint server for biology
Published: April 03, 2026

Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice.

Early changes in the properties of CA3 engram cells explored with a novel viral tool in mice.

Journal: eLife
Published: December 15, 2025

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

Journal: Nature genetics
Published: May 17, 2024

A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy.

A novel AAV9-dual microRNA-vector targeting GRIK2 in the hippocampus as a treatment for mesial temporal lobe epilepsy.

Journal: Molecular therapy. Methods & clinical development
Published: May 01, 2024

Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration.

Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration.

Journal: Cell reports
Published: October 12, 2022

GluK2 Is a Target for Gene Therapy in Drug-Resistant Temporal Lobe Epilepsy.

GluK2 Is a Target for Gene Therapy in Drug-Resistant Temporal Lobe Epilepsy.

Journal: Annals of neurology
Published: August 31, 2022

Presenilin and APP Regulate Synaptic Kainate Receptors.

Presenilin and APP Regulate Synaptic Kainate Receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience
Published: February 10, 2022

Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease.

Impaired plasticity of intrinsic excitability in the dentate gyrus alters spike transfer in a mouse model of Alzheimer's disease.

Journal: Neurobiology of disease
Published: January 22, 2021

Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration.

Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration.

Journal: Cell reports
Published: July 16, 2020

Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice.

Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice.

Journal: Frontiers in molecular neuroscience
Published: July 13, 2017

PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.

PGE2-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.

Journal: Neurobiology of aging
Published: June 29, 2016
Showing 1-11 of 11

Last Updated: 09/26/2026