Shamini G. Shekeran

5 Hospital Drive
169609, Singapore

Last Updated: 09/26/2026

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Found 14 publications

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.

Journal: International journal of molecular sciences

Published: June 02, 2022

Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis.

Thyroid Hormone Decreases Hepatic Steatosis, Inflammation, and Fibrosis in a Dietary Mouse Model of Nonalcoholic Steatohepatitis.

Journal: Thyroid : official journal of the American Thyroid Association

Published: March 23, 2022

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.

IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells.

Journal: iScience

Published: February 28, 2022

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis.

IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis.

Journal: International journal of molecular sciences

Published: February 21, 2022

Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.

Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.

Journal: Journal of hepatology

Published: December 04, 2021

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.

Journal: Nature communications

Published: November 02, 2021

Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.

Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.

Journal: Nature communications

Published: September 28, 2021

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.

Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts.

Journal: Frontiers in molecular biosciences

Published: July 13, 2021

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.

A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome.

Journal: Journal of the American Society of Nephrology : JASN

Published: April 29, 2021

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.

Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis.

Journal: Scientific reports

Published: November 05, 2020

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH.

Journal: Nature communications

Published: March 18, 2020

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.

Journal: Science translational medicine

Published: January 07, 2020

Showing 1-12 of 14

Last Updated: 09/26/2026