Shan Chen

866 Yu Hang Tang Road
Hangzhou, 310058, China

Last Updated: 09/26/2026

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Found 16 publications

Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Design, Synthesis and Biological Evaluation of Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Journal: Journal of medicinal chemistry

Published: December 01, 2025

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.

Integration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.

Journal: Nature biotechnology

Published: November 17, 2025

Discovery and Biological Evaluation of Novel, Potent, and Orally Available CBLB Inhibitors.

Discovery and Biological Evaluation of Novel, Potent, and Orally Available CBLB Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 12, 2025

Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Discovery of Novel, Potent, Selective, and Orally Available DGKα Inhibitors for the Treatment of Tumors.

Journal: Journal of medicinal chemistry

Published: September 08, 2025

AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging.

AI-driven toolset for IPF and aging research associates lung fibrosis with accelerated aging.

Journal: Aging

Published: January 17, 2025

A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial.

A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial.

Journal: Nature medicine

Published: December 19, 2024

Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

Journal: Nature communications

Published: August 28, 2024

Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor.

Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor.

Journal: Nature biotechnology

Published: April 03, 2024

PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery.

PandaOmics: An AI-Driven Platform for Therapeutic Target and Biomarker Discovery.

Journal: Journal of chemical information and modeling

Published: February 26, 2024

Genomic and transcriptome analyses reveal potential contributors to erucic acid biosynthesis in seeds of rapeseed (Brassica napus).

Genomic and transcriptome analyses reveal potential contributors to erucic acid biosynthesis in seeds of rapeseed (Brassica napus).

Journal: TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

Published: January 25, 2024

Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia.

Discovery of Novel and Potent Prolyl Hydroxylase Domain-Containing Protein (PHD) Inhibitors for The Treatment of Anemia.

Journal: Journal of medicinal chemistry

Published: January 08, 2024

Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.

Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer.

Journal: Journal of medicinal chemistry

Published: December 26, 2023

Showing 1-12 of 16

Last Updated: 09/26/2026