Shaohua Yao

National Key Laboratory Of Biotherapy
Chengdu, 610041, China

Last Updated: 09/26/2026

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Found 60 publications

Recent advances in base editing technology and its applications in disease therapy.

Recent advances in base editing technology and its applications in disease therapy.

Journal: Biotechnology advances

Published: June 08, 2026

Lipid Nanoparticle-Delivered mRNA Therapy Corrects Neonatal Murine MPS I-H.

Lipid Nanoparticle-Delivered mRNA Therapy Corrects Neonatal Murine MPS I-H.

Journal: Human gene therapy

Published: March 26, 2026

Reporter-based screening identifies small-molecule CBL0137 as an enhancer of CRISPR cytosine base editor and prime editor via p53 activation and NF-κB inhibition.

Reporter-based screening identifies small-molecule CBL0137 as an enhancer of CRISPR cytosine base editor and prime editor via p53 activation and NF-κB inhibition.

Journal: New biotechnology

Published: November 12, 2025

Harnessing nucleotide metabolism to control glycosylase base editing outcomes.

Harnessing nucleotide metabolism to control glycosylase base editing outcomes.

Journal: Theranostics

Published: September 23, 2025

Comparative evaluation of liver-directed knockin strategies with viral and nonviral vectors in mouse inherited disease models.

Comparative evaluation of liver-directed knockin strategies with viral and nonviral vectors in mouse inherited disease models.

Journal: Molecular therapy : the journal of the American Society of Gene Therapy

Published: May 29, 2025

Glucocorticoid pre-administration improves LNP-mRNA mediated protein replacement and genome editing therapies.

Glucocorticoid pre-administration improves LNP-mRNA mediated protein replacement and genome editing therapies.

Journal: International journal of pharmaceutics

Published: November 14, 2024

Identification of c.146G > A mutation in a Fabry patient and its correction by customized Cas9 base editors in vitro.

Identification of c.146G > A mutation in a Fabry patient and its correction by customized Cas9 base editors in vitro.

Journal: International journal of biological macromolecules

Published: September 05, 2024

Discovery of a potent inhibitor targeting the cap-binding domain of the PB2 subunit of influenza RNA-dependent RNA polymerase.

Discovery of a potent inhibitor targeting the cap-binding domain of the PB2 subunit of influenza RNA-dependent RNA polymerase.

Journal: Biochemical and biophysical research communications

Published: July 26, 2023

DnaQ mediates directional spacer acquisition in the CRISPR-Cas system by a time-dependent mechanism.

DnaQ mediates directional spacer acquisition in the CRISPR-Cas system by a time-dependent mechanism.

Journal: Innovation (Cambridge (Mass.))

Published: April 10, 2023

Erratum: HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing.

Erratum: HDAC inhibitors improve CRISPR-Cas9 mediated prime editing and base editing.

Journal: Molecular therapy. Nucleic acids

Published: October 17, 2022

Targeted, programmable, and precise tandem duplication in the mammalian genome.

Targeted, programmable, and precise tandem duplication in the mammalian genome.

Journal: Genome research

Published: August 29, 2022

Recent advances in therapeutic CRISPR-Cas9 genome editing: mechanisms and applications.

Recent advances in therapeutic CRISPR-Cas9 genome editing: mechanisms and applications.

Journal: Molecular biomedicine

Published: August 27, 2022

Showing 1-12 of 60

Last Updated: 09/26/2026