Sharon M. Gowan

London, ENG SM25NG, United Kingdom

Last Updated: 09/26/2026

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Found 16 publications

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer.

Mediator Kinase Inhibitor Selectivity and Activity in Colorectal Cancer.

Journal: ACS chemical biology

Published: July 02, 2025

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones.

Journal: Journal of medicinal chemistry

Published: April 07, 2023

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.

Journal: Journal of medicinal chemistry

Published: April 05, 2023

Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay-Biological Implications.

Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay-Biological Implications.

Journal: Cells

Published: September 16, 2022

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo.

Journal: Journal of medicinal chemistry

Published: June 02, 2022

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.

Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders.

Journal: Journal of medicinal chemistry

Published: April 11, 2020

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.

De novo phosphatidylcholine synthesis is required for autophagosome membrane formation and maintenance during autophagy.

Journal: Autophagy

Published: September 14, 2019

Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy.

Microbiota- and Radiotherapy-Induced Gastrointestinal Side-Effects (MARS) Study: A Large Pilot Study of the Microbiome in Acute and Late-Radiation Enteropathy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research

Published: March 21, 2019

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.

Journal: British journal of cancer

Published: February 23, 2018

Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma.

Immunoassays for the quantification of ALK and phosphorylated ALK support the evaluation of on-target ALK inhibitors in neuroblastoma.

Journal: Molecular oncology

Published: December 16, 2016

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.

Journal: eLife

Published: August 21, 2016

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Journal: Nature chemical biology

Published: April 08, 2015

Showing 1-12 of 16

Last Updated: 09/26/2026