Shawn Mcguirk

Montreal, QC H3G1Y6, Canada

Last Updated: 09/26/2026

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Found 16 publications

Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1.

Spatiotemporal modeling of chemoresistance evolution in breast tumors uncovers dependencies on SLC38A7 and SLC46A1.

Journal: Cell reports
Published: November 07, 2022

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.

PGC-1s shape epidermal physiology by modulating keratinocyte proliferation and terminal differentiation.

Journal: iScience
Published: July 21, 2022

HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.

HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin.

Journal: Oncogene
Published: August 11, 2021

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.

Resistance to different anthracycline chemotherapeutics elicits distinct and actionable primary metabolic dependencies in breast cancer.

Journal: eLife
Published: November 24, 2020

Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.

Altered mitochondrial fusion drives defensive glutathione synthesis in cells able to switch to glycolytic ATP production.

Journal: Biochimica et biophysica acta. Molecular cell research
Published: June 25, 2020

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4.

Inhibition of DNMT1 and ERRα crosstalk suppresses breast cancer via derepression of IRF4.

Journal: Oncogene
Published: May 08, 2020

Metabolic Fitness and Plasticity in Cancer Progression.

Metabolic Fitness and Plasticity in Cancer Progression.

Journal: Trends in cancer
Published: October 01, 2019

Estrogen-related receptors are targetable ROS sensors.

Estrogen-related receptors are targetable ROS sensors.

Journal: Genes & development
Published: July 23, 2019

Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.

Peroxisome proliferator-activated receptor γ coactivator 1α regulates mitochondrial calcium homeostasis, sarcoplasmic reticulum stress, and cell death to mitigate skeletal muscle aging.

Journal: Aging cell
Published: October 26, 2018

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer.

Journal: Cancer research
Published: November 30, 2017

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

Journal: Molecular cell
Published: January 12, 2017

PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs.

PGC-1α Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs.

Journal: Cell metabolism
Published: October 20, 2016
Showing 1-12 of 16

Last Updated: 09/26/2026