Shengyong Y. Yang

Cancer Center And State Key Laboratory Of Biotherapy
Chengdu, 610041, China

Last Updated: 09/26/2026

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Found 143 publications

Identification of a Potent and Selective Small-Molecule Inhibitor Targeting the nNOS-PDZ Domain that Exhibits Rapid In Vivo Antidepressant Efficacy.

Identification of a Potent and Selective Small-Molecule Inhibitor Targeting the nNOS-PDZ Domain that Exhibits Rapid In Vivo Antidepressant Efficacy.

Journal: Journal of medicinal chemistry

Published: June 03, 2026

Fragment-Aware Contrastive Learning Framework for Molecular Property Prediction.

Fragment-Aware Contrastive Learning Framework for Molecular Property Prediction.

Journal: Journal of chemical information and modeling

Published: April 22, 2026

Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.

Small-molecule inhibition of YTHDC1 as a strategy against acute myeloid leukemia in mouse models.

Journal: Science translational medicine

Published: February 04, 2026

Discovery and Structure-Activity Relationship Studies of Diazepine Derivatives as a New Class of Ferroptosis Inhibitors with Potent Efficacy in the Doxorubicin-Induced Cardiomyopathy Model.

Discovery and Structure-Activity Relationship Studies of Diazepine Derivatives as a New Class of Ferroptosis Inhibitors with Potent Efficacy in the Doxorubicin-Induced Cardiomyopathy Model.

Journal: Journal of medicinal chemistry

Published: January 30, 2026

Discovery of a Potent and Selective Cell-Active Inhibitor of Histidine-N1 Methyltransferase METTL9.

Discovery of a Potent and Selective Cell-Active Inhibitor of Histidine-N1 Methyltransferase METTL9.

Journal: Angewandte Chemie (International ed. in English)

Published: January 16, 2026

Discovery of Deuterated 3,4-Dihydro-benzo[e][1,4]diazepine-2,5-dione Derivatives as Potent, Selective and Orally Bioavailable ROCK2 Inhibitors.

Discovery of Deuterated 3,4-Dihydro-benzo[e][1,4]diazepine-2,5-dione Derivatives as Potent, Selective and Orally Bioavailable ROCK2 Inhibitors.

Journal: Journal of medicinal chemistry

Published: November 25, 2025

Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity.

Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity.

Journal: Journal of medicinal chemistry

Published: September 11, 2025

An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases.

An intrinsic loop-mediated structural stability modulating inhibitor potency in the SADS-CoV and SARS-CoV-2 main proteases.

Journal: PLoS pathogens

Published: August 19, 2025

Acquired resistance to immunotherapy by physical barriers with cancer cell-expressing collagens in non-small cell lung cancer.

Acquired resistance to immunotherapy by physical barriers with cancer cell-expressing collagens in non-small cell lung cancer.

Journal: Proceedings of the National Academy of Sciences of the United States of America

Published: June 11, 2025

A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers.

A blood-brain barrier-like vascular gate limits immunotherapy efficacy in neuroendocrine cancers.

Journal: Cell

Published: May 28, 2025

Correction to: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways.

Correction to: TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways.

Journal: Signal transduction and targeted therapy

Published: March 04, 2025

Discovery of 4-((quinolin-8-ylthio)methyl)benzamide derivatives as a new class of SARS-CoV-2 nsp13 inhibitors.

Discovery of 4-((quinolin-8-ylthio)methyl)benzamide derivatives as a new class of SARS-CoV-2 nsp13 inhibitors.

Journal: Bioorganic & medicinal chemistry letters

Published: January 27, 2025

Showing 1-12 of 143

Last Updated: 09/26/2026