Shicheng Xu

Jiang Su Key Laboratory Of Drug Design And Optimization And Department Of Medicinal Chemistry
Nanjing, 210009, China

Last Updated: 09/26/2026

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Found 8 publications

Discovery of a Biased Kelch-like ECH-Associated Protein 1-p62 (Keap1-p62) Protein-Protein Interaction (PPI) Inhibitor for the Management of p62 Aberrant Hepatocellular Carcinoma.

Discovery of a Biased Kelch-like ECH-Associated Protein 1-p62 (Keap1-p62) Protein-Protein Interaction (PPI) Inhibitor for the Management of p62 Aberrant Hepatocellular Carcinoma.

Journal: Journal of medicinal chemistry

Published: May 30, 2026

Harnessing the E3 Ligase KLHL12 for Tumor-Selective Protein Degradation.

Harnessing the E3 Ligase KLHL12 for Tumor-Selective Protein Degradation.

Journal: Angewandte Chemie (International ed. in English)

Published: May 01, 2026

Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists.

Discovery of Selenium-Containing Derivatives as Potent and Orally Bioavailable GLP-1R Agonists.

Journal: Journal of medicinal chemistry

Published: January 17, 2025

Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.

Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management.

Journal: European journal of medicinal chemistry

Published: December 20, 2024

A Keap1-recruiting BRD4 degrader offers a single-molecular polypharmacology approach for the treatment of metabolic dysfunction-associated steatohepatitis.

A Keap1-recruiting BRD4 degrader offers a single-molecular polypharmacology approach for the treatment of metabolic dysfunction-associated steatohepatitis.

Journal: Free radical biology & medicine

Published: November 20, 2024

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope.

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope.

Journal: Acta pharmaceutica Sinica. B

Published: December 15, 2021

Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects.

Design and synthesis of Grp94 selective inhibitors based on Phe199 induced fit mechanism and their anti-inflammatory effects.

Journal: European journal of medicinal chemistry

Published: March 23, 2021

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.

Journal: Cell chemical biology

Published: November 24, 2020

Showing 1-8 of 8

Last Updated: 09/26/2026