Shigeharu Harada

Kyoto, Japan

Last Updated: 09/26/2026

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Found 38 publications

Modulation of succinyl-CoA:3-ketoacid CoA transferase activity by a single amino acid residue in acetate:succinate CoA transferase from Trypanosoma brucei, the causative agent of African sleeping sickness.

Modulation of succinyl-CoA:3-ketoacid CoA transferase activity by a single amino acid residue in acetate:succinate CoA transferase from Trypanosoma brucei, the causative agent of African sleeping sickness.

Journal: Protein science : a publication of the Protein Society

Published: October 05, 2025

Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase including catalytic intermediates suggest an ordered Bi-Bi reaction mechanism.

Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase including catalytic intermediates suggest an ordered Bi-Bi reaction mechanism.

Journal: Scientific reports

Published: April 23, 2025

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.

Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.

Journal: Genes

Published: October 20, 2020

Structural basis for substrate specificity of l-methionine decarboxylase.

Structural basis for substrate specificity of l-methionine decarboxylase.

Journal: Protein science : a publication of the Protein Society

Published: October 20, 2020

The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei.

The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei.

Journal: Biochimica et biophysica acta. Bioenergetics

Published: June 09, 2020

Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box.

Identification of Plasmodium falciparum Mitochondrial Malate: Quinone Oxidoreductase Inhibitors from the Pathogen Box.

Journal: Genes

Published: May 10, 2019

Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase.

Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase.

Journal: Biochimica et biophysica acta. Bioenergetics

Published: December 20, 2018

Novel Characteristics of Mitochondrial Electron Transport Chain from Eimeria tenella.

Novel Characteristics of Mitochondrial Electron Transport Chain from Eimeria tenella.

Journal: Genes

Published: November 28, 2018

Calorimetric Study of Micelle Formation of Alkylammonium Chlorides in Water.

Calorimetric Study of Micelle Formation of Alkylammonium Chlorides in Water.

Journal: Journal of oleo science

Published: November 09, 2018

SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.

SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase.

Journal: ACS medicinal chemistry letters

Published: June 21, 2018

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.

Journal: Frontiers in pharmacology

Published: March 05, 2018

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.

Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.

Journal: European journal of medicinal chemistry

Published: November 30, 2017

Showing 1-12 of 38

Last Updated: 09/26/2026