Shinichi Kondo

Fujisawa, Japan

Last Updated: 09/26/2026

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Found 10 publications

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat.

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat.

Journal: Epilepsia
Published: September 10, 2024

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models.

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models.

Journal: Neuroscience research
Published: March 15, 2024

Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy.

Cholesterol 24-hydroxylase is a novel pharmacological target for anti-ictogenic and disease modification effects in epilepsy.

Journal: Neurobiology of disease
Published: April 06, 2022

Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.

Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor.

Journal: Epilepsia
Published: December 23, 2021

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice.

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor, reduces seizures and premature death in Dravet syndrome mice.

Journal: Epilepsia
Published: May 27, 2021

Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation.

Anti-sortilin1 Antibody Up-Regulates Progranulin via Sortilin1 Down-Regulation.

Journal: Frontiers in neuroscience
Published: July 22, 2020

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.

Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice.

Journal: Scientific reports
Published: July 15, 2020

Kanamycin and its derivative, arbekacin: significance and impact.

Kanamycin and its derivative, arbekacin: significance and impact.

Journal: The Journal of antibiotics
Published: August 29, 2017

Pharmacological properties of a novel and potent γ-secretase modulator as a therapeutic option for the treatment of Alzheimer's disease.

Pharmacological properties of a novel and potent γ-secretase modulator as a therapeutic option for the treatment of Alzheimer's disease.

Journal: Brain research
Published: September 17, 2015

Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice.

Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice.

Journal: Brain research
Published: September 17, 2015
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Last Updated: 09/26/2026