Shiqian Chen
London, ENG, United Kingdom
Last Updated: 09/26/2026
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Found 9 publications
Spatially diffuse cAMP signalling with oppositely biased GLP-1 receptor agonists in β-cells despite differences in receptor localisation.
Journal: Molecular metabolism
Published: July 30, 2025
Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons.
Journal: Cellular signalling
Published: January 24, 2024
Abolishing β-arrestin recruitment is necessary for the full metabolic benefits of G protein-biased glucagon-like peptide-1 receptor agonists.
Journal: Diabetes, obesity & metabolism
Published: March 23, 2023
Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells.
Journal: Endocrinology
Published: December 05, 2022
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.
Journal: Nature genetics
Published: September 18, 2021
Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1.
Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1.
Journal: Biochemical pharmacology
Published: March 22, 2021
Ligand-Specific Factors Influencing GLP-1 Receptor Post-Endocytic Trafficking and Degradation in Pancreatic Beta Cells.
Journal: International journal of molecular sciences
Published: October 07, 2020
The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists.
Journal: ACS pharmacology & translational science
Published: February 24, 2020
Showing 1-9 of 9
Last Updated: 09/26/2026