Shiyang Sun

Beijing, 100039, China

Last Updated: 09/26/2026

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Found 25 publications

Discovery of Highly Potent and Selective IKZF2 Degraders for Cancer Immunotherapy.

Discovery of Highly Potent and Selective IKZF2 Degraders for Cancer Immunotherapy.

Journal: Journal of medicinal chemistry

Published: April 07, 2026

Structure-Based Discovery of Novel, Highly Potent VEGFR2 Inhibitors with a Naphthalene Scaffold against a Broad Range of Solid Tumors.

Structure-Based Discovery of Novel, Highly Potent VEGFR2 Inhibitors with a Naphthalene Scaffold against a Broad Range of Solid Tumors.

Journal: Journal of medicinal chemistry

Published: March 20, 2026

Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers.

Discovery of Novel Potent Triple IKZF1/2/3 Degraders for the Treatment of Hematological Cancers.

Journal: Journal of medicinal chemistry

Published: August 01, 2025

Novel Highly Potent c-Met Degraders against a Broad Range of Cancers.

Novel Highly Potent c-Met Degraders against a Broad Range of Cancers.

Journal: Journal of medicinal chemistry

Published: July 16, 2025

Discovery and Characterization of Novel IKZF1/3 Glue Degraders against Multiple Hematological Cancer Cell Lines.

Discovery and Characterization of Novel IKZF1/3 Glue Degraders against Multiple Hematological Cancer Cell Lines.

Journal: Oncology research

Published: March 04, 2025

Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.

Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.

Journal: Journal of hematology & oncology

Published: June 22, 2024

The Discovery of Novel α2a Adrenergic Receptor Agonists Only Coupling to Gαi/O Proteins by Virtual Screening.

The Discovery of Novel α2a Adrenergic Receptor Agonists Only Coupling to Gαi/O Proteins by Virtual Screening.

Journal: International journal of molecular sciences

Published: April 26, 2024

Novel Scaffold Agonists of the α2A Adrenergic Receptor Identified via Ensemble-Based Strategy.

Novel Scaffold Agonists of the α2A Adrenergic Receptor Identified via Ensemble-Based Strategy.

Journal: Molecules (Basel, Switzerland)

Published: February 07, 2024

Exploration and structure-activity relationship research of benzenesulfonamide derivatives as potent TRPV4 inhibitors for treating acute lung injury.

Exploration and structure-activity relationship research of benzenesulfonamide derivatives as potent TRPV4 inhibitors for treating acute lung injury.

Journal: Bioorganic chemistry

Published: January 12, 2024

Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation.

Discovery of highly potent and selective KRASG12C degraders by VHL-recruiting PROTACs for the treatment of tumors with KRASG12C-Mutation.

Journal: European journal of medicinal chemistry

Published: September 01, 2023

Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations.

Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations.

Journal: Acta pharmaceutica Sinica. B

Published: November 15, 2022

Discovery of highly potent and selective CRBN-recruiting EGFRL858R/T790M degraders in vivo.

Discovery of highly potent and selective CRBN-recruiting EGFRL858R/T790M degraders in vivo.

Journal: European journal of medicinal chemistry

Published: April 18, 2022

Showing 1-12 of 25

Last Updated: 09/26/2026