Shoko Takehara

Yonago, 6838503, Japan

Last Updated: 09/26/2026

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Found 20 publications

Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model.

Full-length human dystrophin on human artificial chromosome compensates for mouse dystrophin deficiency in a Duchenne muscular dystrophy mouse model.

Journal: Scientific reports
Published: December 01, 2022

Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes.

Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans-chromosomic mouse line expressing human UGT2 enzymes.

Journal: Pharmacology research & perspectives
Published: July 08, 2022

A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features.

A transchromosomic rat model with human chromosome 21 shows robust Down syndrome features.

Journal: American journal of human genetics
Published: October 06, 2021

Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice.

Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice.

Journal: Scientific reports
Published: July 01, 2021

Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice.

Quantitative prediction of P-glycoprotein-mediated drug-drug interactions and intestinal absorption using humanized mice.

Journal: British journal of pharmacology
Published: December 04, 2020

A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21.

A non-mosaic transchromosomic mouse model of down syndrome carrying the long arm of human chromosome 21.

Journal: eLife
Published: February 20, 2020

CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.

CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.

Journal: Molecular pharmacology
Published: May 22, 2019

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Journal: Proceedings of the National Academy of Sciences of the United States of America
Published: February 06, 2019

Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals
Published: March 04, 2018

Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Journal: The AAPS journal
Published: October 23, 2017

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology.

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology.

Journal: Scientific reports
Published: July 24, 2017

Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.

Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.

Journal: The Journal of steroid biochemistry and molecular biology
Published: December 26, 2015
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Last Updated: 09/26/2026