Shu Shimada

Tokyo, Japan

Last Updated: 09/26/2026

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Found 46 publications

H4K5 lactylation - ENO2 loop drives glycolysis and HCC progression.

H4K5 lactylation - ENO2 loop drives glycolysis and HCC progression.

Journal: JHEP reports : innovation in hepatology

Published: August 11, 2025

Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis.

Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis.

Journal: Cancer science

Published: July 30, 2025

Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models.

Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models.

Journal: EBioMedicine

Published: June 11, 2025

PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer.

PAD2-Mediated Histone Citrullination Drives Tumor Progression by Enhancing Cell Proliferation and Modifying the Microenvironment in Pancreatic Cancer.

Journal: Molecular cancer research : MCR

Published: November 23, 2024

Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC.

Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC.

Journal: Hepatology (Baltimore, Md.)

Published: September 05, 2024

Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer.

Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer.

Journal: Oncogene

Published: July 22, 2024

Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma.

Identification and clinical implications of endogenous retrovirus elements suppressed by SETDB1 in hepatocellular carcinoma.

Journal: JHEP reports : innovation in hepatology

Published: June 25, 2024

ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.

ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.

Journal: Cell reports. Medicine

Published: January 18, 2024

The chronicles of hepatocellular carcinoma classification: Subtyping, modeling, and treatment.

The chronicles of hepatocellular carcinoma classification: Subtyping, modeling, and treatment.

Journal: Hepatology (Baltimore, Md.)

Published: August 24, 2023

Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC.

Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC.

Journal: Hepatology communications

Published: April 12, 2023

Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma.

Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in non-viral hepatocellular carcinoma.

Journal: Scientific reports

Published: March 09, 2023

RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer.

RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer.

Journal: Journal of gastroenterology

Published: July 28, 2022

Showing 1-12 of 46

Last Updated: 09/26/2026