Shuangwei Liu

The State Key Laboratory Of Medicinal Chemical Biology
Changhongjie, 300071, China

Last Updated: 09/26/2026

Save publications for later

Sign Up

Not sure about your diagnosis?

Check Your Symptoms

Found 20 publications

Discovery of a Selective DNMT1 Degrader with a Unique Molecular Glue Mechanism as a Potential Therapeutic Agent for Acute Myeloid Leukemia.

Discovery of a Selective DNMT1 Degrader with a Unique Molecular Glue Mechanism as a Potential Therapeutic Agent for Acute Myeloid Leukemia.

Journal: Journal of medicinal chemistry

Published: March 24, 2026

Structural optimization of AR and AR-V7 degraders incorporating silicon-based hydrophobic tags for treatment of castration-resistant prostate cancer.

Structural optimization of AR and AR-V7 degraders incorporating silicon-based hydrophobic tags for treatment of castration-resistant prostate cancer.

Journal: European journal of medicinal chemistry

Published: December 02, 2025

Photocatalyzed Nitrene Insertion into C-O Bonds: Access to Benzisoxazoline-3-ones.

Photocatalyzed Nitrene Insertion into C-O Bonds: Access to Benzisoxazoline-3-ones.

Journal: Organic letters

Published: November 17, 2025

USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts.

USP5 inhibition enables potential therapy for t(8;21) AML through ubiquitin-mediated AML1-ETO degradation in patient-derived xenografts.

Journal: Science translational medicine

Published: September 24, 2025

Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment.

Translational Research on the Oral Delivery of the Cytotoxic PROTAC Molecule via Tumor-Targeting Prodrug Strategy for Triple-Negative Breast Cancer Treatment.

Journal: Journal of medicinal chemistry

Published: September 22, 2025

Lactate metabolism and epigenetic reprogramming drive c-KIT hyperactivation to mediate Gilteritinib resistance: Rationale for c-KIT degraders over kinase inhibitors.

Lactate metabolism and epigenetic reprogramming drive c-KIT hyperactivation to mediate Gilteritinib resistance: Rationale for c-KIT degraders over kinase inhibitors.

Journal: Acta pharmaceutica Sinica. B

Published: August 05, 2025

Identification of a Potent and Selective CDK9 Degrader as a Targeted Therapeutic Option for the Treatment of Small-Cell Lung Cancer.

Identification of a Potent and Selective CDK9 Degrader as a Targeted Therapeutic Option for the Treatment of Small-Cell Lung Cancer.

Journal: Journal of medicinal chemistry

Published: February 03, 2025

Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.

Development of Novel Silicon-Based Hydrophobic Tags (SiHyT) for Targeted Proteins Degradation.

Journal: Journal of medicinal chemistry

Published: December 02, 2024

Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells.

Discovery of novel sitolactone derivative leading to PANoptosis and differentiation of acute myeloid leukemia cells.

Journal: European journal of medicinal chemistry

Published: October 30, 2024

Fe(III)-Triggered Radical Arylation of Arene Moieties from Cyclopropanols to Construct Dibenzocyclohepta/octanones: Synthesis of N-Acetylcolchinol-O-methyl ether.

Fe(III)-Triggered Radical Arylation of Arene Moieties from Cyclopropanols to Construct Dibenzocyclohepta/octanones: Synthesis of N-Acetylcolchinol-O-methyl ether.

Journal: Organic letters

Published: July 09, 2024

Design, synthesis and evaluation of a pyrazolo[3,4-d]pyrimidine derivative as a novel and potent TGFβ1R1 inhibitor.

Design, synthesis and evaluation of a pyrazolo[3,4-d]pyrimidine derivative as a novel and potent TGFβ1R1 inhibitor.

Journal: European journal of medicinal chemistry

Published: February 23, 2024

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.

Journal: Acta pharmaceutica Sinica. B

Published: February 06, 2024

Showing 1-12 of 20

Last Updated: 09/26/2026