Shuichi Sekine

Chiba, Japan

Last Updated: 09/26/2026

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Found 37 publications

StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells.

StemPanTox: A fast and wide-target drug assessment system for tailor-made safety evaluations using personalized iPS cells.

Journal: iScience

Published: December 21, 2021

Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells.

Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells.

Journal: Journal of pharmaceutical sciences

Published: February 17, 2021

Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening.

Hypoxia/reoxygenation exacerbates drug-induced cytotoxicity by opening mitochondrial permeability transition pore: Possible application for toxicity screening.

Journal: Toxicology in vitro : an international journal published in association with BIBRA

Published: March 24, 2020

Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients.

Development of a next generation risk assessment framework for the evaluation of skin sensitisation of cosmetic ingredients.

Journal: Regulatory toxicology and pharmacology : RTP

Published: January 16, 2020

Mechanism-based integrated assay systems for the prediction of drug-induced liver injury.

Mechanism-based integrated assay systems for the prediction of drug-induced liver injury.

Journal: Toxicology and applied pharmacology

Published: December 25, 2019

Functional modulation of liver mitochondria in lipopolysaccharide/drug co-treated rat liver injury model.

Functional modulation of liver mitochondria in lipopolysaccharide/drug co-treated rat liver injury model.

Journal: The Journal of toxicological sciences

Published: December 10, 2019

Mild depolarization is involved in troglitazone-induced liver mitochondrial membrane permeability transition via mitochondrial iPLA2 activation.

Mild depolarization is involved in troglitazone-induced liver mitochondrial membrane permeability transition via mitochondrial iPLA2 activation.

Journal: The Journal of toxicological sciences

Published: November 12, 2019

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver.

Successful energy shift from glycolysis to mitochondrial oxidative phosphorylation in freshly isolated hepatocytes from humanized mice liver.

Journal: Toxicology in vitro : an international journal published in association with BIBRA

Published: October 09, 2019

Inhibition of biliary network reconstruction by benzbromarone delays recovery from pre-existing liver injury.

Inhibition of biliary network reconstruction by benzbromarone delays recovery from pre-existing liver injury.

Journal: Toxicology

Published: November 06, 2018

In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome.

In vitro bile acid-dependent hepatocyte toxicity assay system using human induced pluripotent stem cell-derived hepatocytes: Current status and disadvantages to overcome.

Journal: Drug metabolism and pharmacokinetics

Published: October 18, 2018

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.

Journal: Bioorganic & medicinal chemistry letters

Published: August 22, 2018

Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat.

Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat.

Journal: The Journal of toxicological sciences

Published: May 11, 2018

Showing 1-12 of 37

Last Updated: 09/26/2026