Si Chen

99 Shangda Road
Shanghai, 200444, China

Last Updated: 09/26/2026

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Found 13 publications

Discovery of Stapled Peptide MYC Degrader with Potent In Vivo Activities for Triple-Negative Breast Cancer Therapy.

Discovery of Stapled Peptide MYC Degrader with Potent In Vivo Activities for Triple-Negative Breast Cancer Therapy.

Journal: Journal of medicinal chemistry

Published: July 14, 2026

Discovery of Guanidyl-Stapled Aurein1.2 Peptides with Potent In Vivo Antimicrobial Activities.

Discovery of Guanidyl-Stapled Aurein1.2 Peptides with Potent In Vivo Antimicrobial Activities.

Journal: Journal of medicinal chemistry

Published: June 19, 2026

Mirror-Peptidizer: In Silico Mirror-Image Screening Enables De Novo Design of D-Peptide Binders without D-Protein Synthesis.

Mirror-Peptidizer: In Silico Mirror-Image Screening Enables De Novo Design of D-Peptide Binders without D-Protein Synthesis.

Journal: Research (Washington, D.C.)

Published: March 23, 2026

Design, synthesis and anti-AML activity of guanidyl stapled peptide targeting MLAA-34/MST3 interaction.

Design, synthesis and anti-AML activity of guanidyl stapled peptide targeting MLAA-34/MST3 interaction.

Journal: European journal of medicinal chemistry

Published: February 02, 2026

A Top-Down Design Approach for Generating a Peptide PROTAC Drug Targeting Androgen Receptor for Androgenetic Alopecia Therapy.

A Top-Down Design Approach for Generating a Peptide PROTAC Drug Targeting Androgen Receptor for Androgenetic Alopecia Therapy.

Journal: Journal of medicinal chemistry

Published: June 05, 2024

The Bioactive Compounds of Epimedium and Their Potential Mechanism of Action in Treating Osteoporosis: A Network Pharmacology and Experimental Validation Study.

The Bioactive Compounds of Epimedium and Their Potential Mechanism of Action in Treating Osteoporosis: A Network Pharmacology and Experimental Validation Study.

Journal: Pharmaceuticals (Basel, Switzerland)

Published: April 24, 2024

Design, Synthesis, and Anti-Osteoporotic Characterization of Arginine N-Glycosylated Teriparatide Analogs via the Silver-catalyzed Solid-Phase Glycosylation Strategy.

Design, Synthesis, and Anti-Osteoporotic Characterization of Arginine N-Glycosylated Teriparatide Analogs via the Silver-catalyzed Solid-Phase Glycosylation Strategy.

Journal: Journal of medicinal chemistry

Published: January 09, 2024

Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice.

Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice.

Journal: Acta pharmaceutica Sinica. B

Published: February 09, 2023

Multimodal data fusion for supervised learning-based identification of USP7 inhibitors: a systematic comparison.

Multimodal data fusion for supervised learning-based identification of USP7 inhibitors: a systematic comparison.

Journal: Journal of cheminformatics

Published: July 13, 2022

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression.

Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression.

Journal: Acta pharmaceutica Sinica. B

Published: February 08, 2021

Design, synthesis, and biological evaluation of stapled ascaphin-8 peptides.

Design, synthesis, and biological evaluation of stapled ascaphin-8 peptides.

Journal: Bioorganic & medicinal chemistry

Published: December 20, 2020

Integrated metabolomics and network pharmacology approach to exploring the potential mechanism of tianxiang capsule for treating motion sickness.

Integrated metabolomics and network pharmacology approach to exploring the potential mechanism of tianxiang capsule for treating motion sickness.

Journal: Journal of ethnopharmacology

Published: December 07, 2020

Showing 1-12 of 13

Last Updated: 09/26/2026