Sieto Bosgra
Utrecht, UT, Netherlands
Last Updated: 09/26/2026
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Found 23 publications
Preclinical Comparison of Two CD3xB7H4 Bispecific Antibodies for Solid Tumor Therapy Reveals CD3 Affinity-Dependent Potency and Tolerability Tradeoffs.
Journal: Molecular cancer therapeutics
Published: January 13, 2026
Safety and Efficacy of HexaBody-DR5/DR5 in Malignant Solid Tumors: Phase 1/2a Results and Translational Insights Into Observed Hepatotoxicity.
Journal: Clinical and translational science
Published: November 24, 2025
An asymptotic description of a basic FcRn-regulated clearance mechanism and its implications for PBPK modelling of large antibodies.
Journal: Journal of pharmacokinetics and pharmacodynamics
Published: January 18, 2024
OSWG Recommended Approaches to the Nonclinical Pharmacokinetic (ADME) Characterization of Therapeutic Oligonucleotides.
Journal: Nucleic acid therapeutics
Published: August 17, 2023
Next Generation Exon 51 Skipping Antisense Oligonucleotides for Duchenne Muscular Dystrophy.
Journal: Nucleic acid therapeutics
Published: April 10, 2023
Preclinical anti-tumour activity of HexaBody-CD38, a next-generation CD38 antibody with superior complement-dependent cytotoxic activity.
Journal: EBioMedicine
Published: December 12, 2022
The Pharmacokinetics of 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy.
Journal: Nucleic acid therapeutics
Published: August 21, 2019
Suppression of Mutant Protein Expression in SCA3 and SCA1 Mice Using a CAG Repeat-Targeting Antisense Oligonucleotide.
Journal: Molecular therapy. Nucleic acids
Published: May 21, 2019
Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.
Journal: Nucleic acid therapeutics
Published: January 24, 2019
Assessment of Dermal Absorption of Aluminum from a Representative Antiperspirant Formulation Using a 26 Al Microtracer Approach.
Journal: Clinical and translational science
Published: March 19, 2018
Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.
Journal: Archives of toxicology
Published: October 09, 2015
To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics.
Journal: Clinical pharmacokinetics
Published: August 06, 2015
Last Updated: 09/26/2026