Silvio Aprile

Novara, 28100, Italy

Last Updated: 09/26/2026

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Found 50 publications

Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP-2 Signaling.

Discovery of a Dual IDO1/TDO Inhibitor That Modulates Enzymatic Activity and IDO1/SHP-2 Signaling.

Journal: Journal of medicinal chemistry
Published: July 22, 2026

Bacillus subtilis AC7 Fermentation on Rice Husk Substrate: A Sustainable Approach for Lipopeptide Biosurfactant Production.

Bacillus subtilis AC7 Fermentation on Rice Husk Substrate: A Sustainable Approach for Lipopeptide Biosurfactant Production.

Journal: Microorganisms
Published: March 31, 2026

Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy.

Development of PROTACs Targeting the Moonlighting Enzyme Nicotinamide Phosphoribosyltransferase (NAMPT) for Breast Cancer Therapy.

Journal: Journal of medicinal chemistry
Published: February 19, 2026

An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation.

An adamantane-based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation.

Journal: The FEBS journal
Published: July 22, 2024

Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation.

Exploring the pharmaceutical potential of ammonium organotrifluoroborate functional group: Comprehensive chemical, metabolic, and plasma stability evaluation.

Journal: European journal of medicinal chemistry
Published: July 02, 2024

The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators.

The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: Soft and hard vanilloid/cannabinoid modulators.

Journal: European journal of medicinal chemistry
Published: May 06, 2024

Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration.

Spray-Dried Powder Containing Cannabigerol: A New Extemporaneous Emulgel for Topical Administration.

Journal: Pharmaceutics
Published: November 08, 2023

Correction to "An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline".

Correction to "An Unexpected Deuterium-Induced Metabolic Switch in Doxophylline".

Journal: ACS medicinal chemistry letters
Published: October 31, 2023

Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics.

Selective inhibition of indoleamine and tryptophan 2,3-dioxygenases: Comparative study on kynurenine pathway in cell lines via LC-MS/MS-based targeted metabolomics.

Journal: Journal of pharmaceutical and biomedical analysis
Published: June 29, 2023

A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment.

A Selective ALDH1A3 Inhibitor Impairs Mesothelioma 3-D Multicellular Spheroid Growth and Neutrophil Recruitment.

Journal: International journal of molecular sciences
Published: March 16, 2023

Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer.

Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer.

Journal: Pharmaceuticals (Basel, Switzerland)
Published: November 23, 2022

A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs.

A Versatile and Sustainable Multicomponent Platform for the Synthesis of Protein Degraders: Proof-of-Concept Application to BRD4-Degrading PROTACs.

Journal: Journal of medicinal chemistry
Published: November 02, 2022
Showing 1-12 of 50

Last Updated: 09/26/2026