Simon A. Osborne

Mill Hill
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 17 publications

Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs.

Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs.

Journal: Frontiers in microbiology

Published: September 04, 2020

Eye care in the intensive care unit during the COVID-19 pandemic and beyond.

Eye care in the intensive care unit during the COVID-19 pandemic and beyond.

Journal: Anaesthesia

Published: May 27, 2020

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites.

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites.

Journal: Journal of medicinal chemistry

Published: October 01, 2019

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.

Journal: Bioorganic & medicinal chemistry letters

Published: July 01, 2019

Treatment outcomes of lateral canthotomy and cantholysis for orbital compartment syndrome.

Treatment outcomes of lateral canthotomy and cantholysis for orbital compartment syndrome.

Journal: The British journal of oral & maxillofacial surgery

Published: October 30, 2018

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.

Journal: Bioorganic & medicinal chemistry letters

Published: September 23, 2018

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).

Journal: Bioorganic & medicinal chemistry letters

Published: June 06, 2018

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses.

Journal: Scientific reports

Published: January 19, 2018

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.

Journal: Nature communications

Published: February 20, 2017

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Journal: The Journal of biological chemistry

Published: November 29, 2015

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.

Journal: Antimicrobial agents and chemotherapy

Published: July 20, 2015

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.

Journal: The Journal of biological chemistry

Published: November 21, 2014

Showing 1-12 of 17

Last Updated: 09/26/2026