Simon Krah

Merck Healthcare KGaA, Frankfurter Str. 250
Darmstadt, HE 64293, Germany

Last Updated: 09/26/2026

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Found 51 publications

Generation and Characterization of Bispecific VHH-Derived Surrogate Agonists Mimicking the Function of IL-18.

Generation and Characterization of Bispecific VHH-Derived Surrogate Agonists Mimicking the Function of IL-18.

Journal: Methods in molecular biology (Clifton, N.J.)
Published: May 13, 2026

Antigen-directed single domain antibody-based TNFR1 agonists elicit preferential killing of HER2-overexpressing cancer cells.

Antigen-directed single domain antibody-based TNFR1 agonists elicit preferential killing of HER2-overexpressing cancer cells.

Journal: iScience
Published: October 16, 2025

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities.

Taming interleukin-12: Engineering of bispecific antibody-based IL-12 mimetics with biased agonism capacities.

Journal: Protein science : a publication of the Protein Society
Published: October 22, 2024

Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics.

Taming the beast: engineering strategies and biomedical potential of antibody-based cytokine mimetics.

Journal: Expert opinion on biological therapy
Published: February 22, 2024

Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers.

Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers.

Journal: mAbs
Published: February 19, 2024

Engineering hydrophobicity and manufacturability for optimized biparatopic antibody-drug conjugates targeting c-MET.

Engineering hydrophobicity and manufacturability for optimized biparatopic antibody-drug conjugates targeting c-MET.

Journal: mAbs
Published: January 12, 2024

Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.

Bovine ultralong CDR-H3 derived knob paratopes elicit potent TNF-α neutralization and enable the generation of novel adalimumab-based antibody architectures with augmented features.

Journal: Biological chemistry
Published: December 14, 2023

A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody-Drug Conjugates.

A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody-Drug Conjugates.

Journal: International journal of molecular sciences
Published: November 20, 2023

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization.

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization.

Journal: mAbs
Published: September 28, 2023

Construction of Semisynthetic Shark vNAR Yeast Surface Display Antibody Libraries.

Construction of Semisynthetic Shark vNAR Yeast Surface Display Antibody Libraries.

Journal: Methods in molecular biology (Clifton, N.J.)
Published: September 07, 2023

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.

Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition.

Journal: mAbs
Published: July 20, 2023

Facile One-Step Generation of Camelid VHH and Avian scFv Libraries for Phage Display by Golden Gate Cloning.

Facile One-Step Generation of Camelid VHH and Avian scFv Libraries for Phage Display by Golden Gate Cloning.

Journal: Methods in molecular biology (Clifton, N.J.)
Published: July 05, 2023
Showing 1-12 of 51

Last Updated: 09/26/2026