Sini M. Kinnunen

Helsinki, Finland

Last Updated: 09/26/2026

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Found 15 publications

Genotype-Dependent Effects of Mechanical Stretch and GATA4-Targeted Compound 3i-1262 in Cardiomyopathy Patient-Derived hiPSC-Cardiomyocytes.

Genotype-Dependent Effects of Mechanical Stretch and GATA4-Targeted Compound 3i-1262 in Cardiomyopathy Patient-Derived hiPSC-Cardiomyocytes.

Journal: Basic & clinical pharmacology & toxicology

Published: December 29, 2025

GATA4-targeted compounds induce apoptosis and diminish viability of hepatoblastoma cells.

GATA4-targeted compounds induce apoptosis and diminish viability of hepatoblastoma cells.

Journal: PloS one

Published: March 06, 2025

Affinity chromatography reveals direct binding of the GATA4-NKX2-5 interaction inhibitor (3i-1000) with GATA4.

Affinity chromatography reveals direct binding of the GATA4-NKX2-5 interaction inhibitor (3i-1000) with GATA4.

Journal: Scientific reports

Published: October 17, 2023

Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound.

Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound.

Journal: Stem cell research & therapy

Published: May 12, 2023

GSK3β Serine 389 Phosphorylation Modulates Cardiomyocyte Hypertrophy and Ischemic Injury.

GSK3β Serine 389 Phosphorylation Modulates Cardiomyocyte Hypertrophy and Ischemic Injury.

Journal: International journal of molecular sciences

Published: October 29, 2021

GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line.

GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line.

Journal: Stem cell research & therapy

Published: January 07, 2021

GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes.

GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes.

Journal: Archives of toxicology

Published: October 28, 2019

Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.

Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.

Journal: Journal of medicinal chemistry

Published: August 22, 2019

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds.

Journal: Archives of toxicology

Published: February 06, 2018

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.

Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4-NKX2-5 Interaction.

Journal: Scientific reports

Published: November 17, 2017

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.

Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5.

Journal: Journal of medicinal chemistry

Published: September 01, 2017

Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling.

Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling.

Journal: Small (Weinheim an der Bergstrasse, Germany)

Published: April 21, 2017

Showing 1-12 of 15

Last Updated: 09/26/2026