Siu L. Lam

Vancouver, BC V5Z4H4, Canada

Last Updated: 09/26/2026

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Found 9 publications

MiniPromoters Ple384 (TH) and Ple388 (PITX3) for targeting midbrain dopaminergic neurons in mice and monkeys.

MiniPromoters Ple384 (TH) and Ple388 (PITX3) for targeting midbrain dopaminergic neurons in mice and monkeys.

Journal: Scientific reports
Published: October 20, 2025

First pilot study of intravenous rAAV-PAX6 gene therapy increases retinal-ganglion-cell-layer thickness and Notch1 transcription in a mouse model of aniridia.

First pilot study of intravenous rAAV-PAX6 gene therapy increases retinal-ganglion-cell-layer thickness and Notch1 transcription in a mouse model of aniridia.

Journal: Gene therapy
Published: August 13, 2025

ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons.

ABE8e Corrects Pax6-Aniridic Variant in Humanized Mouse ESCs and via LNPs in Ex Vivo Cortical Neurons.

Journal: Ophthalmology and therapy
Published: March 12, 2023

Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells.

Human MiniPromoters for ocular-rAAV expression in ON bipolar, cone, corneal, endothelial, Müller glial, and PAX6 cells.

Journal: Gene therapy
Published: October 08, 2020

Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia.

Germline CRISPR/Cas9-Mediated Gene Editing Prevents Vision Loss in a Novel Mouse Model of Aniridia.

Journal: Molecular therapy. Methods & clinical development
Published: February 19, 2020

Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.

Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.

Journal: Genetics
Published: December 20, 2018

New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina.

New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina.

Journal: Human gene therapy
Published: August 01, 2018

PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina.

PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina.

Journal: Molecular therapy. Methods & clinical development
Published: April 01, 2016

rAAV-compatible MiniPromoters for restricted expression in the brain and eye.

rAAV-compatible MiniPromoters for restricted expression in the brain and eye.

Journal: Molecular brain
Published: January 21, 2016
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Last Updated: 09/26/2026