Sonia Lain

Stockholm, AB, Sweden

Last Updated: 09/26/2026

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Found 33 publications

Disrupting Notch signalling by a small molecule inhibiting dihydroorotate dehydrogenase activity.

Disrupting Notch signalling by a small molecule inhibiting dihydroorotate dehydrogenase activity.

Journal: Scientific reports

Published: October 23, 2025

Correction: Modulation of p53 C-Terminal Acetylation by Mdm2, p14ARF, and Cytoplasmic SirT2.

Correction: Modulation of p53 C-Terminal Acetylation by Mdm2, p14ARF, and Cytoplasmic SirT2.

Journal: Molecular cancer therapeutics

Published: December 01, 2023

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

Journal: Nature communications

Published: August 18, 2023

Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage.

Retinoblastoma vulnerability to combined de novo and salvage pyrimidine ribonucleotide synthesis pharmacologic blockage.

Journal: Heliyon

Published: May 12, 2023

Correction: Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells.

Correction: Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells.

Journal: Cell death discovery

Published: November 30, 2022

Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells.

Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells.

Journal: Cell death discovery

Published: August 18, 2022

Asymmetric inheritance of cytoophidia could contribute to determine cell fate and plasticity: The onset of alternative differentiation patterns in daughter cells may rely on the acquisition of either CTPS or IMPDH cytoophidia: The onset of alternative differentiation patterns in daughter cells may rely on the acquisition of either CTPS or IMPDH cytoophidia.

Asymmetric inheritance of cytoophidia could contribute to determine cell fate and plasticity: The onset of alternative differentiation patterns in daughter cells may rely on the acquisition of either CTPS or IMPDH cytoophidia: The onset of alternative differentiation patterns in daughter cells may rely on the acquisition of either CTPS or IMPDH cytoophidia.

Journal: BioEssays : news and reviews in molecular, cellular and developmental biology

Published: July 01, 2022

DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance.

DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance.

Journal: iScience

Published: January 14, 2021

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.

Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability.

Journal: Journal of medicinal chemistry

Published: March 28, 2020

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.

Journal: The Journal of biological chemistry

Published: December 04, 2019

Modulating pyrimidine ribonucleotide levels for the treatment of cancer.

Modulating pyrimidine ribonucleotide levels for the treatment of cancer.

Journal: Cancer & metabolism

Published: September 19, 2019

Small molecule activators of the p53 response.

Small molecule activators of the p53 response.

Journal: Journal of molecular cell biology

Published: September 11, 2018

Showing 1-12 of 33

Last Updated: 09/26/2026