Sonke Behrends
Braunschweig, NI, Germany
Last Updated: 09/26/2026
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Found 22 publications
Chimeric analysis links increased NO sensitivity to GC-2 domains and higher maximal activity to GC-1.
Journal: Biochemical pharmacology
Published: May 15, 2026
sGC stimulator BAY 41-8543 improves survival and ventricular function in a rat model of doxorubicin-induced cardiomyopathy with nephrotic syndrome.
Journal: British journal of pharmacology
Published: October 30, 2025
Discovery of the first isoform-specific sGC activator: Selective activation of GC-1 by runcaciguat.
Journal: European journal of pharmacology
Published: February 04, 2025
Heterozygous gain of function variant in GUCY1A2 may cause autonomous ovarian hyperfunction.
Journal: European journal of endocrinology
Published: December 12, 2023
Design, synthesis and biological evaluation of new 3,4-dihydroquinoxalin-2(1H)-one derivatives as soluble guanylyl cyclase (sGC) activators.
Journal: Heliyon
Published: September 23, 2022
Combination of strong anion exchange liquid chromatography with microchip capillary electrophoresis sodium dodecyl sulfate for rapid two-dimensional separations of complex protein mixtures.
Journal: Analytical and bioanalytical chemistry
Published: May 26, 2021
Tyrosine 135 of the β1 subunit as binding site of BAY-543: Importance of the Y-x-S-x-R motif for binding and activation by sGC activator drugs.
Journal: European journal of pharmacology
Published: January 10, 2020
Thermal shift assay: Strengths and weaknesses of the method to investigate the ligand-induced thermostabilization of soluble guanylyl cyclase.
Journal: Journal of pharmaceutical and biomedical analysis
Published: September 25, 2019
A novel soluble guanylyl cyclase activator, BR 11257, acts as a non-stabilising partial agonist of sGC.
Journal: Biochemical pharmacology
Published: November 08, 2018
Synergistic stabilisation of NOsGC by cinaciguat and non-hydrolysable nucleotides: Evidence for sGC activator-induced communication between the heme-binding and catalytic domains.
Journal: Biochimica et biophysica acta. Proteins and proteomics
Published: January 10, 2018
Methods to investigate structure and activation dynamics of GC-1/GC-2.
Journal: Nitric oxide : biology and chemistry
Published: December 20, 2017
Last Updated: 09/26/2026