Sophia Lin

3650 Gilmore Way
Burnaby, BC V5G4W8, Canada

Last Updated: 09/26/2026

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Found 18 publications

Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7.

Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7.

Journal: Bioorganic & medicinal chemistry letters

Published: September 20, 2024

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

The contribution of NaV1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and NaV1.6 gain-of-function (GOF) mouse seizure control.

Journal: British journal of pharmacology

Published: December 21, 2023

Development and application of a multiple reaction monitoring method for the simultaneous quantification of sodium channels Nav 1.1, Nav 1.2, and Nav 1.6 in solubilized membrane proteins from stable HEK293 cell lines, rodents, and human brain tissues.

Development and application of a multiple reaction monitoring method for the simultaneous quantification of sodium channels Nav 1.1, Nav 1.2, and Nav 1.6 in solubilized membrane proteins from stable HEK293 cell lines, rodents, and human brain tissues.

Journal: Rapid communications in mass spectrometry : RCM

Published: June 28, 2023

Structure-function relationship of new peptides activating human Nav1.1.

Structure-function relationship of new peptides activating human Nav1.1.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Published: March 23, 2023

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation.

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1: Preclinical Efficacy against Iron Overload and Safety Evaluation.

Journal: The Journal of pharmacology and experimental therapeutics

Published: September 01, 2022

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures.

Pharmacological determination of the fractional block of Nav channels required to impair neuronal excitability and ex vivo seizures.

Journal: Frontiers in cellular neuroscience

Published: June 09, 2022

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human NaV1.7/NaV1.6 Selectivity Ratios.

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human NaV1.7/NaV1.6 Selectivity Ratios.

Journal: Frontiers in cell and developmental biology

Published: October 20, 2021

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats.

Journal: eLife

Published: July 24, 2021

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Identification of aryl sulfonamides as novel and potent inhibitors of NaV1.5.

Journal: Bioorganic & medicinal chemistry letters

Published: April 07, 2021

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

Journal: Journal of medicinal chemistry

Published: March 08, 2021

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy.

Journal: Journal of medicinal chemistry

Published: September 19, 2019

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

Journal: Journal of medicinal chemistry

Published: April 04, 2019

Showing 1-12 of 18

Last Updated: 09/26/2026