Sophie R. Sayers

School Of Life Course Sciences
London, ENG, United Kingdom

Last Updated: 09/26/2026

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Found 12 publications

eNAMPT induces alpha-cell mass expansion but impaired glucagon counter regulatory response.

eNAMPT induces alpha-cell mass expansion but impaired glucagon counter regulatory response.

Journal: Endocrinology
Published: June 22, 2025

NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice.

NAMPT activity plays a key role in driving autoimmune processes that mediate beta-cell death and type 1 diabetes development in mice.

Journal: Cell death & disease
Published: June 16, 2025

Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress.

Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress.

Journal: Free radical biology & medicine
Published: May 05, 2021

Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome.

Psoriatic skin inflammation induces a pre-diabetic phenotype via the endocrine actions of skin secretome.

Journal: Molecular metabolism
Published: April 29, 2020

Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion.

Identification of a subset of trace amine-associated receptors and ligands as potential modulators of insulin secretion.

Journal: Biochemical pharmacology
Published: August 22, 2019

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

Structure-functional changes in eNAMPT at high concentrations mediate mouse and human beta cell dysfunction in type 2 diabetes.

Journal: Diabetologia
Published: February 21, 2019

Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake.

Carnosine scavenging of glucolipotoxic free radicals enhances insulin secretion and glucose uptake.

Journal: Scientific reports
Published: June 06, 2017

Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment.

Monomeric eNAMPT in the development of experimental diabetes in mice: a potential target for type 2 diabetes treatment.

Journal: Diabetologia
Published: May 06, 2016

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance.

Journal: PloS one
Published: December 08, 2015

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

Disallowance of Acot7 in β-Cells Is Required for Normal Glucose Tolerance and Insulin Secretion.

Journal: Diabetes
Published: September 03, 2015

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.

Loss of Liver Kinase B1 (LKB1) in Beta Cells Enhances Glucose-stimulated Insulin Secretion Despite Profound Mitochondrial Defects.

Journal: The Journal of biological chemistry
Published: January 17, 2015

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.

The Peutz-Jeghers kinase LKB1 suppresses polyp growth from intestinal cells of a proglucagon-expressing lineage in mice.

Journal: Disease models & mechanisms
Published: September 06, 2014
Showing 1-12 of 12

Last Updated: 09/26/2026